Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 820067..820766 Replicon chromosome
Accession NZ_CP073630
Organism Proteus terrae subsp. cibarius strain S24-2-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEF19_RS03845 Protein ID WP_159364182.1
Coordinates 820380..820766 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEF19_RS03840 Protein ID WP_075671318.1
Coordinates 820067..820387 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEF19_RS03815 816274..816549 - 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -
KEF19_RS03820 816604..817227 - 624 WP_006534608.1 guanylate kinase -
KEF19_RS03825 817533..818150 - 618 WP_006534609.1 trimeric intracellular cation channel family protein -
KEF19_RS03830 818287..819573 + 1287 WP_196729173.1 DUF3748 domain-containing protein -
KEF19_RS03835 819679..819999 + 321 WP_075671316.1 hypothetical protein -
KEF19_RS03840 820067..820387 - 321 WP_075671318.1 helix-turn-helix domain-containing protein Antitoxin
KEF19_RS03845 820380..820766 - 387 WP_159364182.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEF19_RS03850 820918..822990 - 2073 WP_075671322.1 glycine--tRNA ligase subunit beta -
KEF19_RS03855 823000..823905 - 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
KEF19_RS03860 824143..824727 + 585 WP_109419307.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14388.78 Da        Isoelectric Point: 10.0463

>T199955 WP_159364182.1 NZ_CP073630:c820766-820380 [Proteus terrae subsp. cibarius]
MVIYKTKMFKNSFKKMPINDATLIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Download         Length: 387 bp

>T199955 NZ_CP097668:c193106-192690 [Klebsiella pneumoniae]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12068.99 Da        Isoelectric Point: 10.0482

>AT199955 WP_075671318.1 NZ_CP073630:c820387-820067 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT199955 NZ_CP097668:c193333-193103 [Klebsiella pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References