Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2409435..2409961 Replicon chromosome
Accession NZ_CP073624
Organism Escherichia coli strain AW1.7

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KD735_RS11880 Protein ID WP_000323025.1
Coordinates 2409674..2409961 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KD735_RS11875 Protein ID WP_000534858.1
Coordinates 2409435..2409674 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KD735_RS11855 (2405355) 2405355..2407664 - 2310 Protein_2310 dimethyl sulfoxide reductase subunit A -
KD735_RS11860 (2407718) 2407718..2408686 - 969 WP_077898063.1 IS5 family transposase -
KD735_RS11865 (2408717) 2408717..2408902 - 186 Protein_2312 FlxA-like family protein -
KD735_RS11870 (2409105) 2409105..2409410 - 306 WP_001326990.1 protein YdfV -
KD735_RS11875 (2409435) 2409435..2409674 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KD735_RS11880 (2409674) 2409674..2409961 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KD735_RS11885 (2410033) 2410033..2410188 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KD735_RS11890 (2410405) 2410405..2410656 + 252 WP_000980994.1 protein Rem -
KD735_RS11895 (2410723) 2410723..2411001 + 279 WP_012304870.1 hypothetical protein -
KD735_RS11900 (2411003) 2411003..2412052 + 1050 WP_001265198.1 DUF968 domain-containing protein -
KD735_RS11905 (2412066) 2412066..2412818 + 753 WP_001047135.1 antitermination protein -
KD735_RS11910 (2413096) 2413096..2413185 - 90 WP_120795389.1 hypothetical protein -
KD735_RS11915 (2413240) 2413240..2413452 - 213 WP_000087756.1 cold shock-like protein CspF -
KD735_RS11920 (2413753) 2413753..2413968 + 216 WP_000066484.1 cold shock-like protein CspB -
KD735_RS11925 (2414332) 2414332..2414502 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KD735_RS11930 (2414722) 2414722..2414937 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2401387..2455569 54182
- flank IS/Tn - - 2407718..2408641 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T199922 WP_000323025.1 NZ_CP073624:2409674-2409961 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T199922 NZ_CP097660:315322-315690 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT199922 WP_000534858.1 NZ_CP073624:2409435-2409674 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT199922 NZ_CP097660:315104-315325 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References