Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1190300..1190967 Replicon chromosome
Accession NZ_CP073624
Organism Escherichia coli strain AW1.7

Toxin (Protein)


Gene name ypjF Uniprot ID A0A2I8SC83
Locus tag KD735_RS05735 Protein ID WP_054626383.1
Coordinates 1190300..1190629 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2I8SA04
Locus tag KD735_RS05740 Protein ID WP_054626382.1
Coordinates 1190650..1190967 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KD735_RS05730 (1185356) 1185356..1189933 + 4578 Protein_1120 AIDA repeat-containing protein -
KD735_RS05735 (1190300) 1190300..1190629 - 330 WP_054626383.1 TA system toxin CbtA family protein Toxin
KD735_RS05740 (1190650) 1190650..1190967 - 318 WP_054626382.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KD735_RS05745 (1190985) 1190985..1191206 - 222 WP_054626381.1 DUF987 domain-containing protein -
KD735_RS05750 (1191215) 1191215..1191691 - 477 WP_054626380.1 RadC family protein -
KD735_RS05755 (1191707) 1191707..1192165 - 459 WP_049606139.1 antirestriction protein -
KD735_RS05760 (1192249) 1192249..1192488 - 240 WP_054626379.1 DUF905 domain-containing protein -
KD735_RS05765 (1192588) 1192588..1193496 - 909 WP_064761968.1 Ivy family c-type lysozyme inhibitor -
KD735_RS05770 (1193565) 1193565..1193732 - 168 Protein_1128 DUF4339 domain-containing protein -
KD735_RS05775 (1193770) 1193770..1194465 - 696 WP_054626378.1 hypothetical protein -
KD735_RS05780 (1194692) 1194692..1195519 - 828 WP_054626377.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1178173..1220095 41922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12324.29 Da        Isoelectric Point: 7.1642

>T199912 WP_054626383.1 NZ_CP073624:c1190629-1190300 [Escherichia coli]
MKTLPATTPQAAKLCLPPVAVWQMLLTRLLETHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDRNGF
SWQEQTPYISVVDILRARRSTGLLKNNVK

Download         Length: 330 bp

>T199912 NZ_CP097658:1999138-1999240 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11741.53 Da        Isoelectric Point: 7.0161

>AT199912 WP_054626382.1 NZ_CP073624:c1190967-1190650 [Escherichia coli]
MSKITWGLQRNITPHLGARLVQEGNRLHYLADRASITGKISDAECLKLDVAFPHFISQMELMLTTGEMNPCHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR

Download         Length: 318 bp

>AT199912 NZ_CP097658:c1999247-1999102 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8SC83

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8SA04

References