Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 49488..50167 | Replicon | chromosome |
| Accession | NZ_CP073624 | ||
| Organism | Escherichia coli strain AW1.7 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | KD735_RS00250 | Protein ID | WP_032170241.1 |
| Coordinates | 49488..49829 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | KD735_RS00255 | Protein ID | WP_054626043.1 |
| Coordinates | 49850..50167 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KD735_RS00225 (44987) | 44987..45910 | - | 924 | WP_000535960.1 | carboxylate/amino acid/amine transporter | - |
| KD735_RS00230 (46021) | 46021..47205 | - | 1185 | WP_001172876.1 | sugar efflux transporter | - |
| KD735_RS00235 (47641) | 47641..47763 | - | 123 | Protein_46 | virulence RhuM family protein | - |
| KD735_RS00240 (48038) | 48038..48421 | - | 384 | WP_032170243.1 | hypothetical protein | - |
| KD735_RS25140 (48435) | 48435..48623 | - | 189 | WP_251364672.1 | hypothetical protein | - |
| KD735_RS25145 (48758) | 48758..49195 | + | 438 | WP_251364673.1 | toll/interleukin-1 receptor domain-containing protein | - |
| KD735_RS00250 (49488) | 49488..49829 | - | 342 | WP_032170241.1 | TA system toxin CbtA family protein | Toxin |
| KD735_RS00255 (49850) | 49850..50167 | - | 318 | WP_054626043.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KD735_RS00260 (50186) | 50186..50407 | - | 222 | WP_000691995.1 | DUF987 domain-containing protein | - |
| KD735_RS00265 (50416) | 50416..50892 | - | 477 | WP_001618788.1 | RadC family protein | - |
| KD735_RS00270 (50908) | 50908..51366 | - | 459 | WP_000211838.1 | antirestriction protein | - |
| KD735_RS00275 (51464) | 51464..51703 | - | 240 | WP_032170520.1 | DUF905 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12821.81 Da Isoelectric Point: 10.0426
>T199904 WP_032170241.1 NZ_CP073624:c49829-49488 [Escherichia coli]
MKILPATTSRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQNHINAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNTAVR
MKILPATTSRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQNHINAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNTAVR
Download Length: 342 bp
>T199904 NZ_CP097655:c28320-28171 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 12029.65 Da Isoelectric Point: 7.0262
>AT199904 WP_054626043.1 NZ_CP073624:c50167-49850 [Escherichia coli]
MSNITWGLQRNITPCLGARLVQEGNRLHYLADRTSITGKFSDIECRKLDETFPHFIRQMESMLTTGEMNPHHAHYVILYH
NGFTCEADTLGSCGYVYVAVYSTQR
MSNITWGLQRNITPCLGARLVQEGNRLHYLADRTSITGKFSDIECRKLDETFPHFIRQMESMLTTGEMNPHHAHYVILYH
NGFTCEADTLGSCGYVYVAVYSTQR
Download Length: 318 bp
>AT199904 NZ_CP097655:28365-28424 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|