Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4773103..4774691 Replicon chromosome
Accession NZ_CP073621
Organism Escherichia coli strain CE2050

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KEW59_RS22590 Protein ID WP_001595766.1
Coordinates 4773369..4774691 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KEW59_RS22585 Protein ID WP_001296726.1
Coordinates 4773103..4773369 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEW59_RS22585 (4773103) 4773103..4773369 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KEW59_RS22590 (4773369) 4773369..4774691 + 1323 WP_001595766.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
KEW59_RS22595 (4775089) 4775089..4775988 - 900 WP_001057776.1 LysR family transcriptional regulator -
KEW59_RS22600 (4776128) 4776128..4776436 + 309 WP_001221046.1 hypothetical protein -
KEW59_RS22605 (4776445) 4776445..4777134 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
KEW59_RS22610 (4777208) 4777208..4778155 + 948 WP_000854796.1 aldo/keto reductase -
KEW59_RS22615 (4778258) 4778258..4778413 + 156 WP_001322415.1 hypothetical protein -
KEW59_RS22620 (4778373) 4778373..4778792 + 420 WP_001322416.1 amidohydrolase family protein -
KEW59_RS25425 (4778782) 4778782..4778934 + 153 WP_001322417.1 amidohydrolase family protein -
KEW59_RS22625 (4779085) 4779085..4779657 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49370.02 Da        Isoelectric Point: 8.5830

>T199900 WP_001595766.1 NZ_CP073621:4773369-4774691 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGVNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Download         Length: 1323 bp

>T199900 NZ_CP097654:4127132-4127234 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT199900 WP_001296726.1 NZ_CP073621:4773103-4773369 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp

>AT199900 NZ_CP097654:c4127241-4127096 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References