Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1676381..1676903 Replicon chromosome
Accession NZ_CP073621
Organism Escherichia coli strain CE2050

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag KEW59_RS07860 Protein ID WP_001105433.1
Coordinates 1676381..1676671 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag KEW59_RS07865 Protein ID WP_000212715.1
Coordinates 1676661..1676903 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEW59_RS07845 (1671549) 1671549..1673204 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
KEW59_RS07850 (1673598) 1673598..1675736 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
KEW59_RS07855 (1675916) 1675916..1676380 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KEW59_RS07860 (1676381) 1676381..1676671 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEW59_RS07865 (1676661) 1676661..1676903 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KEW59_RS07870 (1677095) 1677095..1677481 - 387 WP_001232246.1 cytochrome b562 -
KEW59_RS07875 (1677664) 1677664..1679016 - 1353 WP_001162173.1 metalloprotease PmbA -
KEW59_RS07880 (1679110) 1679110..1679661 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
KEW59_RS07885 (1679811) 1679811..1681184 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T199882 WP_001105433.1 NZ_CP073621:c1676671-1676381 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T199882 NZ_CP097651:2083694-2083796 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT199882 WP_000212715.1 NZ_CP073621:c1676903-1676661 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT199882 NZ_CP097651:c2083803-2083658 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References