Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3192792..3193593 Replicon chromosome
Accession NZ_CP073589
Organism Escherichia coli strain MFDS1006657

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H0JYG3
Locus tag KD154_RS15495 Protein ID WP_001094432.1
Coordinates 3193216..3193593 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7NA60
Locus tag KD154_RS15490 Protein ID WP_001380152.1
Coordinates 3192792..3193169 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KD154_RS15455 (3189443) 3189443..3189904 + 462 WP_000581501.1 IrmA family protein -
KD154_RS25155 (3190040) 3190040..3190129 + 90 WP_112031555.1 DUF905 family protein -
KD154_RS15465 (3190307) 3190307..3191128 + 822 WP_001241714.1 DUF932 domain-containing protein -
KD154_RS15470 (3191128) 3191128..3191328 + 201 WP_001367430.1 hypothetical protein -
KD154_RS15475 (3191462) 3191462..3191935 + 474 WP_000855069.1 antirestriction protein -
KD154_RS15480 (3191950) 3191950..3192426 + 477 WP_033884753.1 RadC family protein -
KD154_RS15485 (3192495) 3192495..3192716 + 222 WP_000692313.1 DUF987 domain-containing protein -
KD154_RS15490 (3192792) 3192792..3193169 + 378 WP_001380152.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
KD154_RS15495 (3193216) 3193216..3193593 + 378 WP_001094432.1 TA system toxin CbtA family protein Toxin
KD154_RS15500 (3193590) 3193590..3194078 + 489 WP_033884750.1 DUF5983 family protein -
KD154_RS15505 (3194090) 3194090..3194287 + 198 WP_000839249.1 DUF957 domain-containing protein -
KD154_RS15510 (3194372) 3194372..3195217 + 846 WP_001280530.1 DUF4942 domain-containing protein -
KD154_RS15515 (3195451) 3195451..3195579 + 129 Protein_3061 RhuM family protein -
KD154_RS15520 (3196009) 3196009..3197193 + 1185 WP_001172876.1 sugar efflux transporter -
KD154_RS15525 (3197304) 3197304..3198227 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14136.99 Da        Isoelectric Point: 6.4729

>T199864 WP_001094432.1 NZ_CP073589:3193216-3193593 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T199864 NZ_CP097646:779768-780178 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTTCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13679.52 Da        Isoelectric Point: 5.8682

>AT199864 WP_001380152.1 NZ_CP073589:3192792-3193169 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT199864 NZ_CP097646:779521-779787 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0JYG3

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7NA60

References