Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2866103..2866903 Replicon chromosome
Accession NZ_CP073589
Organism Escherichia coli strain MFDS1006657

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag KD154_RS14035 Protein ID WP_000342449.1
Coordinates 2866103..2866630 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag KD154_RS14040 Protein ID WP_001277108.1
Coordinates 2866637..2866903 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KD154_RS14010 (2861178) 2861178..2861945 - 768 WP_000082110.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KD154_RS14015 (2861942) 2861942..2863219 - 1278 WP_000803783.1 branched chain amino acid ABC transporter permease LivM -
KD154_RS14020 (2863216) 2863216..2864142 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KD154_RS14025 (2864190) 2864190..2865299 - 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
KD154_RS14030 (2865723) 2865723..2866106 + 384 WP_000778785.1 aspartate 1-decarboxylase autocleavage activator PanM -
KD154_RS14035 (2866103) 2866103..2866630 - 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
KD154_RS14040 (2866637) 2866637..2866903 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
KD154_RS14045 (2867053) 2867053..2868156 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
KD154_RS14050 (2868427) 2868427..2869281 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
KD154_RS14055 (2869526) 2869526..2870584 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
KD154_RS14060 (2870577) 2870577..2871245 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T199862 WP_000342449.1 NZ_CP073589:c2866630-2866103 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T199862 NZ_CP097636:c3191772-3190906 [Aquincola tertiaricarbonis]
ATGAGCCCGGACCTGCAACTGCCTGCCGCCGACCTCGCCGACCTGGACGCCCGCTTTGGCGTGCAGCGCATCGCCGTGGG
TGGCGGCCGCGTGGTGGCGGTGCGGCGCATGGGGCAGGGCCTGCCGGTGGTGTGCCTGCACGGCATCGGCTCGGGCTCGG
CCTCGTGGGTGGAGGTGGCGCCCCTGATCGCGCCGCAGGCCGAGCTGATCGCCTGGGATGCGCCGGGCTACGGCGATTCG
ACGCCGCTGCCGATGGCTGAGCCCCGGGCGACCGACTACGCACAGCGCCTGGCCGAGCTGCTGGATGCGCTGCACATCCA
CCGCTGCGTGCTGGTGGGCCATTCGCTGGGCGCGCTCACTGCCGCCGCGGCGGCACAGCCGGGCGGCCCGCTGGCCGGCC
GCATCGCGCAGCTGCTGCTCATCAGCCCGGCGCGCGGCTATGGGGCGCCCGACCGCGCCGCGCAAGGCGCGCAGGTGCAG
GCCGAACGCCTGGCCACGCTGGCCGAGCTGGGCATCGAGGGCACGGCACGGCTGCGCAGCGGCCGCCTGCTGTCGGCGCA
TGCCCCCGAAGCCGCGCGCCTGCGCGTGCGCTGGAACATGGCACGCCTGAACGAGCACGGCTACCGCCAGGCGGTGGCCC
TGCTGTGCGGCGACGACCTGCTGGCCTACCTGCCTCCGGCCGTGCCGGTGCAGGTGGCCGTGGGTGAGCTGGATGTGATC
ACCCCGCCCGCGGCCTGCGCCGAGGTGGCTGCGGCCTGTGGTGTGCCGCTGCAGCCCATCGCGCAGGCGGGGCATGCCAG
CTACGTGGAGCGGCCCGAAGCCGTGTCCGCGCTGCTGGCCACCTGTCTAGACAAGGCCGCGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT199862 WP_001277108.1 NZ_CP073589:c2866903-2866637 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT199862 NZ_CP097636:c3190877-3190029 [Aquincola tertiaricarbonis]
ATGAGCACCCCCGACGCCGAACTGGCGGACGACGGCCAGGACCGCTACATCGTGCCGGCGCTCGAGCGCGGCCTGCGCAT
CCTGGGCGAGTTCAGCCGCGAGAACCGCACGCTGGGCGCCCCCGAGCTGGCCCGCCGCTTCGGCCTGCCGCGTTCCACCG
TGTTCCGCCTGCTGGCCACGCTGGAAAGCATGGGCTTCATCGAGAAGACCGAAGGCGGCCGCGAATACCGGCTGGGCCTG
GCGGTGCTGCGCCTGGGCTTCGAGTACCTGGCCTCGCTGGAGCTGACCGAGCTGGGCCTGCCCATCCTCAACCGCCTGAG
CGAAGCCATCGGCTACCCGTGCAACCTGGTGGTGCGCGATGGCCGTTCCATCGTCTACGTGGCCAAGGTCACCACGCCCA
CGCCGTTTGCCAGCTCGGTGACGGTAGGCACCCGGCTGCCCGCCCACGCCACCGTGCTGGGCCGCGTGCTGCTGGAAGAC
CTGACCCTGCCCGAGCTGCGGGCCATGTACCCGGAAGACCGGCTGGAAATCTTCTCCCCCAGCACGCCGCGCACGGTGAT
CGAGCTGTTCAACCTGGTGCAGGCCGACCGCGAGCGTGGCCATGTGCAGGGCGAGGGCTTCTTCGAGTCCAACATCTCCA
CCATCGCCGCGCCGGTGCGCGACCACAGCGGCCGCGTGGTGGCGGCGCTGGGTGCCACCATCACCTCGGCCCACATCGAC
GGCGAGCGCATGGACGAGATGGTGCGCCGCGTGCGCGATGCGGCGCAGGAGCTGTCCGCGCTGCTGAACTATGCCCCCGC
CTCGGCCAGCCGCAACGTGGTGCCGCTGCGTGGCGGCAAGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References