Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1839328..1839953 Replicon chromosome
Accession NZ_CP073589
Organism Escherichia coli strain MFDS1006657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KD154_RS09040 Protein ID WP_000911330.1
Coordinates 1839328..1839726 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KD154_RS09045 Protein ID WP_000450524.1
Coordinates 1839726..1839953 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KD154_RS09020 (1835206) 1835206..1835406 + 201 WP_000383836.1 YpfN family protein -
KD154_RS09025 (1835516) 1835516..1836214 - 699 WP_000679823.1 esterase -
KD154_RS09030 (1836288) 1836288..1838303 - 2016 WP_000829327.1 tRNA cytosine(34) acetyltransferase TmcA -
KD154_RS09035 (1838318) 1838318..1839181 - 864 WP_001267507.1 neutral zinc metallopeptidase -
KD154_RS09040 (1839328) 1839328..1839726 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
KD154_RS09045 (1839726) 1839726..1839953 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KD154_RS09050 (1840107) 1840107..1840820 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KD154_RS09055 (1841033) 1841033..1842067 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KD154_RS09060 (1842084) 1842084..1842962 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KD154_RS09065 (1843108) 1843108..1843680 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KD154_RS09070 (1843680) 1843680..1844150 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T199858 WP_000911330.1 NZ_CP073589:c1839726-1839328 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T199858 NZ_CP097635:c1569712-1569059 [Aquincola tertiaricarbonis]
ATGGCCACCGACTACGCCAACCTGCTCAACCCTGAGCGCGCGCGCATCTTCCGGATCATCCACCGCAGCAACCTGCCGTG
GGTGCTGGAGCATGGCCTGCACTGCGGCAACAGCGCGACACGTTCACCGCAGTGGGTCAGCATTGGCAACCAGGAGCTCA
TCGCCAAACGCGCCTCATGGCCCGTTCGCGCGGGGGCGGGCGGGGTGCTGAACGACTATGTCCCGTTCTACTTCACCCCT
TTTTCGCCGATGATGTTGGCCATCAGGACCGGATGGAATGGCGTGCAGCAGCATCGTCCGCAGGACATCCTGATCCTCGT
GTCCGATCTGCACCGGATTTCTGCGCTGGGCCTGACCTGGCTCTTCACCGATACCCATGCCAACAACGGCGTGGTCCGGT
ACTTCCAGCGCGTTGAGGACCTGGCGCAGCTGGACTGGCGCATCCTGCAGCAGCGAGACTTTCGCCGGGACCCCGACGAC
CCGGGCAAGTTCGGCCGCTATCAGGCAGAGGTGCTGGTCCACCGGCAGGTGCCGTTGCAGGGCTTGTCCGGCATCGTCTG
TGCGGATGACGATGGCAAGATGTTGGTCGAGCAAGCCGTGGCGGCAGCCTGCAAACAGCTCCAGGTGGTCACACGTCCTG
GCTGGTATCTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT199858 WP_000450524.1 NZ_CP073589:c1839953-1839726 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT199858 NZ_CP097635:c1569059-1567974 [Aquincola tertiaricarbonis]
ATGATTTCGTACACCCAAGGCAACCTTCTGGAAGCGCGCGTGGATGCGCTGGTCAATACCGTCAACACCGTGGGTGTGAT
GGGGAAGGGCATCGCCTTGATGTTCAAGGAGCGCTTCGAGCGCAACTTCAAGCTGTACGCGGCCGCCTGCAAGGCAGGCG
AAGTCCAGGTGGGGCGGATGTTCGTGACCGAGACTGACGAACTGGAGGCGCCGCGGTGGATCATCAACTTTCCTACGAAG
GACCATTGGCGGAACCCGTCGCGGCTGGAGTGGGTGGAAGCTGGGCTGGTGGACCTGAAGCGGGTGTTGAAGGAACTCAA
CATCCGGTCAGTGGCGATCCCGCCCTTGGGCGCGGGCAACGGCGGCCTCGACTGGGGCGTGGTGAAGGCCTGCATTCACA
AGGCGCTTGCTGACCTCGATGGCGTGGAGGTCGTCGTCTATGAGCCGACTGGCCGTTATCAGAACGTGGCCAAGCGGTCG
GGCGTGCAGGCATTGACCCCTGCGCGTGCGCTGGTGGCGGAAGCGATTCGCCGCTACTGGGTGCTTGGCATGGAATGCAG
CCTGCTCGAGGTGCAAAAGCTCGCCTGGTTCATTGAGCGCAGCCTGAATCACCTGGGACTGCGCAACGACCTGAAGTTGA
ACTTCCGGGCGCACCGGTACGGGCCTTTTGCCACGCACCTCAACCACCTGCTCGACAGCCTCGACGGCAGCTACCTGAAG
TCGGACAAGCGCATCGCGGACGCCGCGCCGTTGGACGTGATCGCGTTCAACGAAGATCGCCAGGAAGTGGTGCAGGCCTA
CCTGAAAAGCGAAGGCAAAGAGGTGGCGCCCGCACTCGAGCTCGTCAGCCGCGTGATCAGCGGCTTCGAGTCGCCGTTCG
GCATGGAGCTGCTTGCCTCAGTGGATTGGCTGATCAGTCGCGAGGGCGTGGCCCCCGAAGTGCCTGCGCTGCTGCACGGC
CTGGCGCATTGGCCGGCCGATCAGGCCGGCGGTGCCGGCCGCCGCAAGCAGCAGATCTTCGATGAGCGAGCCGTTCAGAT
CGCCCTGGATCAGTTGCGCCGCAGCCCGCTGTACGCAGCTGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References