Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2377252..2377823 Replicon chromosome
Accession NZ_CP073588
Organism Shewanella vesiculosa strain M7

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag KDH10_RS10335 Protein ID WP_011638897.1
Coordinates 2377512..2377823 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag KDH10_RS10330 Protein ID WP_011638898.1
Coordinates 2377252..2377512 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDH10_RS10310 (KDH10_002028) 2372412..2373535 + 1124 Protein_1997 ISAs1 family transposase -
KDH10_RS10315 (KDH10_002029) 2373874..2374470 - 597 WP_123884034.1 tyrosine-type recombinase/integrase -
KDH10_RS10320 (KDH10_002030) 2374734..2376358 - 1625 Protein_1999 MCR-4 family phosphoethanolamine--lipid A transferase -
KDH10_RS10325 (KDH10_002031) 2376492..2377082 - 591 WP_011638902.1 recombinase family protein -
KDH10_RS10330 (KDH10_002032) 2377252..2377512 + 261 WP_011638898.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KDH10_RS10335 (KDH10_002033) 2377512..2377823 + 312 WP_011638897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KDH10_RS10340 2377847..2378737 + 891 WP_235781945.1 DUF4158 domain-containing protein -
KDH10_RS10345 (KDH10_002034) 2378748..2380934 + 2187 WP_235781966.1 Tn3 family transposase -
KDH10_RS10350 (KDH10_002035) 2381331..2381690 - 360 WP_011638887.1 DUF6488 family protein -
KDH10_RS10355 (KDH10_002036) 2381722..2382036 - 315 WP_041413220.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T199846 WP_011638897.1 NZ_CP073588:2377512-2377823 [Shewanella vesiculosa]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T199846 NZ_CP097626:c4907751-4907467 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT199846 WP_011638898.1 NZ_CP073588:2377252-2377512 [Shewanella vesiculosa]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT199846 NZ_CP097626:c4907983-4907741 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A883CRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZVH1

References