Detailed information of TA system TA199844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1199823..1200339
• Replicon: chromosome
• Accession: NZ_CP073587
• Organism: Shewanella yunxiaonensis strain FJAT-54481

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KDN34_RS05635
• Protein ID: WP_212595930.1
• Coordinates: 1200070..1200339 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KDN34_RS05630
• Protein ID: WP_212595929.1
• Coordinates: 1199823..1200077 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KDN34_RS05610 (KDN34_05610)	1195743..1196090	-	348	WP_212595925.1	hypothetical protein	-
KDN34_RS05615 (KDN34_05615)	1196083..1197642	-	1560	WP_212595926.1	hypothetical protein	-
KDN34_RS05620 (KDN34_05620)	1198537..1198977	+	441	WP_212595927.1	DUF2384 domain-containing protein	-
KDN34_RS05625 (KDN34_05625)	1199030..1199539	-	510	WP_212595928.1	mobile mystery protein A	-
KDN34_RS05630 (KDN34_05630)	1199823..1200077	+	255	WP_212595929.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KDN34_RS05635 (KDN34_05635)	1200070..1200339	+	270	WP_212595930.1	Txe/YoeB family addiction module toxin	Toxin
KDN34_RS05640 (KDN34_05640)	1200775..1201041	+	267	WP_212595931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KDN34_RS05645 (KDN34_05645)	1201031..1201366	+	336	WP_212595932.1	hypothetical protein	-
KDN34_RS05650 (KDN34_05650)	1201491..1202237	+	747	WP_212595933.1	metallophosphoesterase	-
KDN34_RS05655 (KDN34_05655)	1202515..1202853	-	339	WP_212595934.1	helix-turn-helix transcriptional regulator	-
KDN34_RS05660 (KDN34_05660)	1203228..1203431	-	204	WP_212596537.1	cold-shock protein	-
KDN34_RS05665 (KDN34_05665)	1204138..1205166	+	1029	WP_212595935.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1157818..1202853	45035
	-	flank	IS/Tn	-	-	1194654..1195694	1040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10707.10 Da
• Isoelectric Point: 8.0108

>T199844 WP_212595930.1 NZ_CP073587:1200070-1200339 [Shewanella yunxiaonensis]
MSSRQHILSWTDDAWEDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYVVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T199844 NZ_CP097626:4191524-4191742 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9393.53 Da
• Isoelectric Point: 5.0622

>AT199844 WP_212595929.1 NZ_CP073587:1199823-1200077 [Shewanella yunxiaonensis]
VKIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT199844 NZ_CP097626:4191123-4191497 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG