Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2457543..2458086 Replicon chromosome
Accession NZ_CP073586
Organism Proteiniphilum propionicum strain JNU-WLY501

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KDN43_RS09930 Protein ID WP_238865808.1
Coordinates 2457543..2457842 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KDN43_RS09935 Protein ID WP_238865810.1
Coordinates 2457832..2458086 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDN43_RS09900 (KDN43_09885) 2453195..2453485 - 291 WP_238865795.1 hypothetical protein -
KDN43_RS09905 (KDN43_09890) 2453533..2454009 - 477 WP_238865797.1 hypothetical protein -
KDN43_RS09910 (KDN43_09895) 2454227..2454943 - 717 WP_238865800.1 porin family protein -
KDN43_RS09915 (KDN43_09900) 2454979..2455683 - 705 WP_238865802.1 outer membrane beta-barrel protein -
KDN43_RS09920 (KDN43_09905) 2455707..2456231 - 525 WP_238865804.1 hypothetical protein -
KDN43_RS09925 (KDN43_09910) 2456368..2457126 - 759 WP_238865806.1 Crp/Fnr family transcriptional regulator -
KDN43_RS09930 (KDN43_09915) 2457543..2457842 - 300 WP_238865808.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KDN43_RS09935 (KDN43_09920) 2457832..2458086 - 255 WP_238865810.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KDN43_RS09940 (KDN43_09925) 2458339..2458617 - 279 WP_238865812.1 hypothetical protein -
KDN43_RS09945 (KDN43_09930) 2458658..2459245 - 588 WP_238865814.1 hypothetical protein -
KDN43_RS09950 (KDN43_09935) 2459648..2460016 + 369 WP_238865815.1 group II intron maturase-specific domain-containing protein -
KDN43_RS09955 (KDN43_09940) 2460132..2460365 - 234 WP_238865817.1 two-component regulator propeller domain-containing protein -
KDN43_RS09960 (KDN43_09945) 2460480..2460854 + 375 WP_238865819.1 transposase -
KDN43_RS09965 (KDN43_09950) 2460859..2461200 + 342 WP_238865820.1 IS66 family insertion sequence element accessory protein TnpB -
KDN43_RS09970 (KDN43_09955) 2461292..2461555 + 264 WP_256448701.1 transposase -
KDN43_RS09975 (KDN43_09960) 2461754..2462326 - 573 WP_238865822.1 integrase core domain-containing protein -
KDN43_RS09980 (KDN43_09965) 2462316..2462558 - 243 WP_238865823.1 hypothetical protein -
KDN43_RS09985 (KDN43_09970) 2462579..2462845 - 267 WP_238841705.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(4-69)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 12272.94 Da        Isoelectric Point: 5.9989

>T199843 WP_238865808.1 NZ_CP073586:c2457842-2457543 [Proteiniphilum propionicum]
MKFEISEKAFEDIENIWLYTIESWSVEQADRYFNLLLDEIEYITEHPLSEKNADHIRKNYRYTKVKSHLVFYRYKKSEKK
VEIIRILHHSMDVEERMNE

Download         Length: 300 bp

>T199843 NZ_CP097626:c2756751-2755429 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9592.91 Da        Isoelectric Point: 7.2029

>AT199843 WP_238865810.1 NZ_CP073586:c2458086-2457832 [Proteiniphilum propionicum]
MAKNTSILLGEYFENFINEKVKSGKFASASEVVRTALRLFEQQENKTKILVNELKAGEESGMISNFDREKALSNLHTKYL
HNEI

Download         Length: 255 bp

>AT199843 NZ_CP097626:c2757017-2756751 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References