Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 911200..912767 Replicon plasmid pGJ3-1
Accession NZ_CP073579
Organism Photobacterium sp. GJ3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KDD30_RS21060 Protein ID WP_211650302.1
Coordinates 911200..912522 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KDD30_RS21065 Protein ID WP_211650304.1
Coordinates 912516..912767 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDD30_RS21035 (KDD30_21035) 906615..907409 - 795 WP_211650298.1 EAL domain-containing protein -
KDD30_RS21040 (KDD30_21040) 907710..908414 + 705 WP_249199343.1 HAD family hydrolase -
KDD30_RS21045 (KDD30_21045) 908643..909185 + 543 WP_211651919.1 cytochrome b -
KDD30_RS21050 (KDD30_21050) 909182..909751 + 570 WP_211650300.1 YceI family protein -
KDD30_RS21055 (KDD30_21055) 909966..910964 - 999 WP_249199344.1 tryptophan--tRNA ligase -
KDD30_RS21060 (KDD30_21060) 911200..912522 - 1323 WP_211650302.1 type II toxin-antitoxin system HipA family toxin Toxin
KDD30_RS21065 (KDD30_21065) 912516..912767 - 252 WP_211650304.1 helix-turn-helix domain-containing protein Antitoxin
KDD30_RS21070 (KDD30_21070) 913161..913868 + 708 WP_249199345.1 DUF1223 domain-containing protein -
KDD30_RS21075 (KDD30_21075) 914060..914779 - 720 WP_211650307.1 alpha/beta fold hydrolase -
KDD30_RS21080 (KDD30_21080) 914942..915121 - 180 WP_211650309.1 hypothetical protein -
KDD30_RS21085 (KDD30_21085) 915633..916538 + 906 WP_211651922.1 chemotaxis protein -
KDD30_RS21090 (KDD30_21090) 916654..916959 + 306 WP_211650311.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - vipB/mglB / flp1 / flpC / flpF 1..1690710 1690710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-398)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49764.37 Da        Isoelectric Point: 9.5423

>T199842 WP_211650302.1 NZ_CP073579:c912522-911200 [Photobacterium sp. GJ3]
MVRQLRVLMNGLNVGVFTKEVTGAHTFQYDEAWIHSKKRRAISLSLPLRKARFTGDEVINFFDNLLPDNPQVRERIVARY
DAKTKQPFDLLEKIGRDSVGAITLIPEGQPIPDFKKISATELTAARLEHVLNAYTDNIPLGMVDGNDDFRISIAGAQEKT
ALLKRHDRWYIPNGLTPTTHIIKLPIGEIRTQSSVLDLTTSVDNELICMRLSRAFGLPTASCDVLHAGKVRALAVERFDR
RYAQKEDWIVRLPQEDFCQVSGISPAKKYEVDGGIGIEGIMNHLLGSEIAGEDRRTFMKAQVLFFVLAAIDGHAKNFSLF
LQPNGKYRLTPLYDIISAYPMMGGKGIHERKIKLAMGLKASTGYKRHWYQIQARHFMNTARLVKYSSESMREILEEFQGS
YMSAVDQVGNQLPQDIDENVRDKIFEGIVKSMRRLTLNPA

Download         Length: 1323 bp

>T199842 NZ_CP097626:2021237-2021339 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9313.53 Da        Isoelectric Point: 5.1358

>AT199842 WP_211650304.1 NZ_CP073579:c912767-912516 [Photobacterium sp. GJ3]
VLITSPKQLATHLKDERKSKRLSQEKVADPVGLKQDTVSKFEINPETTSIGTLFRILSSLDLELHLQPKGKSGEPSDEDD
ELW

Download         Length: 252 bp

>AT199842 NZ_CP097626:c2021346-2021201 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References