Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 134028..134938 Replicon plasmid p00001
Accession NZ_CP073378
Organism Klebsiella sp. P1927

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag KB892_RS27900 Protein ID WP_004026354.1
Coordinates 134468..134938 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag KB892_RS27895 Protein ID WP_004181895.1
Coordinates 134028..134471 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB892_RS27870 (KB892_27870) 129065..129271 + 207 WP_004026437.1 hypothetical protein -
KB892_RS27875 (KB892_27875) 129355..129834 + 480 WP_004181843.1 hypothetical protein -
KB892_RS27880 (KB892_27880) 130661..132148 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
KB892_RS27885 (KB892_27885) 132234..132656 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
KB892_RS27890 (KB892_27890) 132656..133927 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
KB892_RS27895 (KB892_27895) 134028..134471 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
KB892_RS27900 (KB892_27900) 134468..134938 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
KB892_RS27905 (KB892_27905) 135048..135308 - 261 WP_004026352.1 hypothetical protein -
KB892_RS27910 (KB892_27910) 135879..137060 - 1182 WP_078207741.1 IS481 family transposase -
KB892_RS27915 (KB892_27915) 137174..137878 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
KB892_RS27920 (KB892_27920) 137943..139193 - 1251 Protein_140 transposase -
KB892_RS27925 (KB892_27925) 139268..139936 - 669 WP_001300294.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / blaTEM-1B / aac(3)-IId / blaSHV-12 / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) rmpA / iutA / iucD / iucC / iucB / iucA 1..299258 299258


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T199829 WP_004026354.1 NZ_CP073378:134468-134938 [Klebsiella sp. P1927]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T199829 NZ_CP097610:1977776-1978102 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAGTG
ATTTACGAAGTCCACCTGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAGTATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT199829 WP_004181895.1 NZ_CP073378:134028-134471 [Klebsiella sp. P1927]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT199829 NZ_CP097610:1978196-1978522 [Pasteurella multocida]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCAAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTCGTCTATTGATCAGCATAATCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References