Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 8503..9029 | Replicon | plasmid p00001 |
| Accession | NZ_CP073378 | ||
| Organism | Klebsiella sp. P1927 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KB892_RS27285 | Protein ID | WP_000323025.1 |
| Coordinates | 8503..8790 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KB892_RS27290 | Protein ID | WP_000534858.1 |
| Coordinates | 8790..9029 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KB892_RS27255 (KB892_27255) | 3549..3782 | - | 234 | WP_004181905.1 | hypothetical protein | - |
| KB892_RS27260 (KB892_27260) | 3861..4208 | - | 348 | WP_004181904.1 | hypothetical protein | - |
| KB892_RS27265 (KB892_27265) | 4364..5431 | - | 1068 | WP_004181903.1 | hypothetical protein | - |
| KB892_RS27270 (KB892_27270) | 6121..6498 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| KB892_RS27275 (KB892_27275) | 6696..7670 | - | 975 | WP_004181899.1 | hypothetical protein | - |
| KB892_RS27280 (KB892_27280) | 8273..8431 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| KB892_RS27285 (KB892_27285) | 8503..8790 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KB892_RS27290 (KB892_27290) | 8790..9029 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KB892_RS31240 | 9054..9158 | + | 105 | Protein_12 | hypothetical protein | - |
| KB892_RS27295 (KB892_27295) | 9292..9708 | - | 417 | Protein_13 | cation-efflux pump | - |
| KB892_RS27300 (KB892_27300) | 9781..10949 | + | 1169 | WP_085929673.1 | IS3-like element ISEc52 family transposase | - |
| KB892_RS27305 (KB892_27305) | 10959..11270 | - | 312 | Protein_15 | transposase | - |
| KB892_RS27310 (KB892_27310) | 11691..13031 | - | 1341 | WP_000589001.1 | ISNCY family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mph(A) / blaTEM-1B / aac(3)-IId / blaSHV-12 / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) | rmpA / iutA / iucD / iucC / iucB / iucA | 1..299258 | 299258 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T199827 WP_000323025.1 NZ_CP073378:c8790-8503 [Klebsiella sp. P1927]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T199827 NZ_CP097608:2124139-2124453 [Pasteurella multocida]
ATGTTTGAGATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAAGATTTGTCGGCTAAAGCAGCTATTCT
TGCTCGTATTAATAGAGCTAAAAATGGTAATTTTGGCGATCACAAATCAGTTGGTGATGGCTTGTATGAAATGAGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTACACACAATACAAAGATGTAACCTATTTGCTAATTTGCGGAGGTGATAAATCT
ACACAGAAAGCAGACATCGCTAAAGCAAAAGTGTTATGGGAAGAGATTAAGCAGAAAGAGGGGGTAAATGTATGA
ATGTTTGAGATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAAGATTTGTCGGCTAAAGCAGCTATTCT
TGCTCGTATTAATAGAGCTAAAAATGGTAATTTTGGCGATCACAAATCAGTTGGTGATGGCTTGTATGAAATGAGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTACACACAATACAAAGATGTAACCTATTTGCTAATTTGCGGAGGTGATAAATCT
ACACAGAAAGCAGACATCGCTAAAGCAAAAGTGTTATGGGAAGAGATTAAGCAGAAAGAGGGGGTAAATGTATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT199827 WP_000534858.1 NZ_CP073378:c9029-8790 [Klebsiella sp. P1927]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT199827 NZ_CP097608:2124450-2124740 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTGAAGCCATTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCCGCATATTTAAG
TGAGGTTTTAGAAACAGGTGATACTAATGAATTTATTTCCGCGCTAGGTGATGTCGCAAGAGCAAGAGGAATGACGGAGT
TAGCAGCAAAAACAGGGTTGGGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACAATA
ATGAAAATTACGCAAGCATTAGGCATTAAACTTGTCCCAACGCACATCTAA
ATGAGTAAAAAAGTAGAATTGAAGCCATTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCCGCATATTTAAG
TGAGGTTTTAGAAACAGGTGATACTAATGAATTTATTTCCGCGCTAGGTGATGTCGCAAGAGCAAGAGGAATGACGGAGT
TAGCAGCAAAAACAGGGTTGGGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACAATA
ATGAAAATTACGCAAGCATTAGGCATTAAACTTGTCCCAACGCACATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|