Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4586140..4586656 Replicon chromosome
Accession NZ_CP073377
Organism Klebsiella sp. P1927

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KB892_RS22915 Protein ID WP_002886902.1
Coordinates 4586140..4586424 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KB892_RS22920 Protein ID WP_002886901.1
Coordinates 4586414..4586656 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB892_RS22890 (KB892_22890) 4581624..4581887 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KB892_RS22895 (KB892_22895) 4582017..4582190 + 174 WP_002886906.1 hypothetical protein -
KB892_RS22900 (KB892_22900) 4582193..4582936 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KB892_RS22905 (KB892_22905) 4583293..4585431 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KB892_RS22910 (KB892_22910) 4585672..4586136 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KB892_RS22915 (KB892_22915) 4586140..4586424 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KB892_RS22920 (KB892_22920) 4586414..4586656 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KB892_RS22925 (KB892_22925) 4586734..4588644 - 1911 WP_004152270.1 PRD domain-containing protein -
KB892_RS22930 (KB892_22930) 4588667..4589821 - 1155 WP_002886900.1 lactonase family protein -
KB892_RS22935 (KB892_22935) 4589887..4590627 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T199823 WP_002886902.1 NZ_CP073377:c4586424-4586140 [Klebsiella sp. P1927]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T199823 NZ_CP097604:594558-594848 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCAGCATATTTAAG
TGAAGTTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTTGCAAGAGCGAGAGGAATGACGGAAT
TAGCAGAAAAAACGGGGTTGGGAAGAGAAAGCCTCTATAAAACATTATCACACGGAAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT199823 WP_002886901.1 NZ_CP073377:c4586656-4586414 [Klebsiella sp. P1927]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT199823 NZ_CP097604:594247-594561 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAGGCGGCTATTCT
TGCTCGTATTAGTCGCGCTAAAAGTGGTAATTTTGGCGATCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGGGCTGGTTATAGGGTTTATTATGCACAATACAAAGATATAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAAATATTGCTAAAGCAAAAGCGTTATGGGAAGAAATTAAGCAGAAAGAGGGGGTAAATGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References