Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 530274..530928 Replicon chromosome
Accession NZ_CP073377
Organism Klebsiella sp. P1927

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag KB892_RS02810 Protein ID WP_004144731.1
Coordinates 530521..530928 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KB892_RS02805 Protein ID WP_002916312.1
Coordinates 530274..530540 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB892_RS02780 (KB892_02780) 525430..526863 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KB892_RS02785 (KB892_02785) 526982..527710 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KB892_RS02790 (KB892_02790) 527760..528071 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KB892_RS02795 (KB892_02795) 528235..528894 + 660 WP_002916317.1 hemolysin III family protein -
KB892_RS02800 (KB892_02800) 529045..530028 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KB892_RS02805 (KB892_02805) 530274..530540 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KB892_RS02810 (KB892_02810) 530521..530928 + 408 WP_004144731.1 protein YgfX Toxin
KB892_RS02815 (KB892_02815) 530935..531456 - 522 WP_002916308.1 flavodoxin FldB -
KB892_RS02820 (KB892_02820) 531557..532453 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KB892_RS02825 (KB892_02825) 532476..533189 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KB892_RS02830 (KB892_02830) 533195..534928 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T199811 WP_004144731.1 NZ_CP073377:530521-530928 [Klebsiella sp. P1927]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T199811 NZ_CP097589:2115583-2115933 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT199811 WP_002916312.1 NZ_CP073377:530274-530540 [Klebsiella sp. P1927]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT199811 NZ_CP097589:2115296-2115577 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References