Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3835123..3835780 Replicon chromosome
Accession NZ_CP073373
Organism Klebsiella sp. P1954

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KB890_RS18480 Protein ID WP_002916310.1
Coordinates 3835370..3835780 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KB890_RS18475 Protein ID WP_002916312.1
Coordinates 3835123..3835389 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB890_RS18450 (3830279) 3830279..3831712 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
KB890_RS18455 (3831831) 3831831..3832559 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KB890_RS18460 (3832609) 3832609..3832920 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KB890_RS18465 (3833084) 3833084..3833743 + 660 WP_002916317.1 hemolysin III family protein -
KB890_RS18470 (3833894) 3833894..3834877 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
KB890_RS18475 (3835123) 3835123..3835389 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KB890_RS18480 (3835370) 3835370..3835780 + 411 WP_002916310.1 protein YgfX Toxin
KB890_RS18485 (3835787) 3835787..3836308 - 522 WP_004144730.1 flavodoxin FldB -
KB890_RS18490 (3836409) 3836409..3837305 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KB890_RS18495 (3837328) 3837328..3838041 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KB890_RS18500 (3838047) 3838047..3839780 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T199792 WP_002916310.1 NZ_CP073373:3835370-3835780 [Klebsiella sp. P1954]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T199792 NZ_CP097576:2100922-2101128 [Microcystis aeruginosa str. Chao 1910]
ATGCCTAATGGAAGACTAACCTATAAGCGAGGAGAGATCTGGTGGGTCGATCTGAAACCCGTTGTTGGTTATGAAACCGA
TAAAGAACGCCCTTGCCTGATTTTACAAAACGATATTGGCAATCAAAATGGAACAACGACAATAGTTGCTCCATTGTTGC
CTGGGAAAAAGACTTATGGTTCTTCGTTACTTGGTATGGTTCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT199792 WP_002916312.1 NZ_CP073373:3835123-3835389 [Klebsiella sp. P1954]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT199792 NZ_CP097576:2100705-2100929 [Microcystis aeruginosa str. Chao 1910]
ATGAGTAAGAAAGTCAGCATAACCTTAGACGACGAAGTTTTGGACTTTGTAGATCGACTAGCAAGCAATCGTAGCCGCTT
TATCAATGATGTTCTCTGGCAAGAGAAGAAAAGGGTTTTTATGAAAGAGCTAGAAGATGCTTATAAAGATCAGGCCAATG
ATCCAGAGATGCAAGAAGAAATTTCTGTCTGGGATATTGCAGTGGGCGATGGTCTAAATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References