Detailed information of TA system TA199789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2598282..2599963
• Replicon: chromosome
• Accession: NZ_CP073373
• Organism: Klebsiella sp. P1954

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KB890_RS12485
• Protein ID: WP_004178299.1
• Coordinates: 2598282..2599199 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KB890_RS12490
• Protein ID: WP_004177809.1
• Coordinates: 2599205..2599963 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KB890_RS12465 (2593588)	2593588..2595108	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
KB890_RS12470 (2595105)	2595105..2596103	+	999	WP_002885172.1	ribose ABC transporter permease	-
KB890_RS12475 (2596134)	2596134..2597075	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KB890_RS12480 (2597150)	2597150..2598157	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
KB890_RS12485 (2598282)	2598282..2599199	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KB890_RS12490 (2599205)	2599205..2599963	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KB890_RS12495 (2600049)	2600049..2600777	-	729	WP_004178298.1	response regulator transcription factor	-
KB890_RS12500 (2601050)	2601050..2603197	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KB890_RS12505 (2603194)	2603194..2603337	-	144	WP_022631365.1	hypothetical protein	-
KB890_RS12510 (2603775)	2603775..2604461	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T199789 WP_004178299.1 NZ_CP073373:c2599199-2598282 [Klebsiella sp. P1954]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T199789 NZ_CP097576:1840828-1841118 [Microcystis aeruginosa str. Chao 1910]
ATGATTGAAATTCGCCAGACTAAAACTTATTCTGAGTGGTTTAGTGGTTTGCGAGATCGCCAAGCAAAAGCGCGTATAGA
CATTCGTATTCGTCGTTTATCTACGGGCAATCCGGGCGATGTTAAGCCAGTAGGACAAGGTGTATCAGAACTGCGAGTTG
ATTATGGTCCAGGCTATCGGGTATATTTTATACAACAAGGTAAGACCTTGATTATCCTCTTGGCAGGAGGAGATAAAAAG
ACTCAAGAACGAGACATCAAAACAGCATTAGATTTAGCCCGTAACTTATAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT199789 WP_004177809.1 NZ_CP073373:c2599963-2599205 [Klebsiella sp. P1954]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT199789 NZ_CP097576:1841128-1841418 [Microcystis aeruginosa str. Chao 1910]
ATGGCTACTATCCAAACCTATCCTTGGGATGCTGCAGATCATCTGCAAACAAAAGAAGATATAGCGGCATATCTTGAAGC
TGCTCTCGAAGATGGTGATCCGAGTTTAATAATAGCAGCATTAGGTGATATTGCCCGCGCTAAAGGAATAACAAATATTG
CTAGTGAAACAGGGTTAGGAAGTGAAAATCTCTGCAAAGCTTTGTTGAGTGAAGGTAATCCAGAGTTTACTACAGTTATT
AGGATTTTACAGGTACTTGGATTACGTCTCCAGATTGTACCCATTACCTAA

Structures

Antitoxin

• AlphaFold DB: A6TH05