Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2442586..2443102 Replicon chromosome
Accession NZ_CP073373
Organism Klebsiella sp. P1954

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KB890_RS11695 Protein ID WP_004178374.1
Coordinates 2442586..2442870 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KB890_RS11700 Protein ID WP_002886901.1
Coordinates 2442860..2443102 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB890_RS11670 (2438070) 2438070..2438378 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
KB890_RS11675 (2438463) 2438463..2438636 + 174 WP_032408826.1 hypothetical protein -
KB890_RS11680 (2438639) 2438639..2439382 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KB890_RS11685 (2439739) 2439739..2441877 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KB890_RS11690 (2442118) 2442118..2442582 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KB890_RS11695 (2442586) 2442586..2442870 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KB890_RS11700 (2442860) 2442860..2443102 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KB890_RS11705 (2443180) 2443180..2445090 - 1911 WP_004178373.1 PRD domain-containing protein -
KB890_RS11710 (2445113) 2445113..2446267 - 1155 WP_004178372.1 lactonase family protein -
KB890_RS11715 (2446334) 2446334..2447074 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T199788 WP_004178374.1 NZ_CP073373:c2442870-2442586 [Klebsiella sp. P1954]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T199788 NZ_CP097576:1432960-1433292 [Microcystis aeruginosa str. Chao 1910]
GTGACATACATTCCAGAACGTGGAGATTTCCTGCGGTTGAGCTTCGACCCACAAATTGGACATGAGCAAATGGGTAATCG
TCCAGCACTGGTGGTAAGCCATATTGATTTTAATCGCAAGATTGGTTTTGCCTTTGTCTGTCCGGTGAGCAATACGCAAC
GCCAGAACCCTTTCTACGTCAAGATTCCAGATGGAGAGGCAGTGACAGGAGTTATCATGGTAGATCAGCTGCGATCGTTG
GACTTCCGAGCGAGAAAAGCGAGCTTTATCGGCAAGTGTCCAGAACAGTTGCTCCAGGATGTTCTCAGAAGAATTAAGCC
GATTCTGTTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT199788 WP_002886901.1 NZ_CP073373:c2443102-2442860 [Klebsiella sp. P1954]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT199788 NZ_CP097576:1432721-1432963 [Microcystis aeruginosa str. Chao 1910]
ATGAAGTCGCAGATTGGACGCTGGGGTAATTCTTTAGCGATTCGGATTCCCAAGTATGCGGTGGAGGCACTGAACCTCAA
TCCTAAGGACGTTGTTGAATGTTCTGTGGAAAACGGAAAGCTAGTAATTGAGCTAATTCAAGCCTTGCCTGAGTTAAGCC
TCGAAGAACTACTGGCTGAGGTTGTTGAATCACCGGAGCCGGAAGTGGATTGGGGACGGCCAATGGGAGAGGAGGTTTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References