199787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2332021..2332831 Replicon chromosome
Accession NZ_CP073373
Organism Klebsiella sp. P1954

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag KB890_RS11255 Protein ID WP_004178461.1
Coordinates 2332021..2332554 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag KB890_RS11260 Protein ID WP_002887278.1
Coordinates 2332565..2332831 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB890_RS11250 (2330852) 2330852..2331973 + 1122 WP_002887282.1 cupin domain-containing protein -
KB890_RS11255 (2332021) 2332021..2332554 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
KB890_RS11260 (2332565) 2332565..2332831 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
KB890_RS11265 (2332934) 2332934..2334367 - 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
KB890_RS11270 (2334357) 2334357..2335040 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
KB890_RS11275 (2335212) 2335212..2336597 + 1386 WP_004178457.1 efflux transporter outer membrane subunit -
KB890_RS11280 (2336615) 2336615..2336959 + 345 WP_004197273.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T199787 WP_004178461.1 NZ_CP073373:c2332554-2332021 [Klebsiella sp. P1954]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T199787 NZ_CP097576:1209214-1209480 [Microcystis aeruginosa str. Chao 1910]
ATGGATAATTGGCAGTTGGTTTTTACCAAACAAGCGAAAAAAGATGCTGAAAAGCTTGCTCGTACTGGTTTGGCAAAACA
AGCTAACGAGTTATTAAATATTCTTAAGTCAAATCCCTATCAATCTTATCCTGTTTATGAGAAACTCAGTGGCGATTTAG
CGAGCTATTATTCCAGACGTATTAATATTCAGCATCGTTTGGTTTATCAGGTTATTCCAGAAGAGAAGGTTGTCAAAATT
ATACGGATGTGGATTCATTATGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT199787 WP_002887278.1 NZ_CP073373:c2332831-2332565 [Klebsiella sp. P1954]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT199787 NZ_CP097576:1208961-1209221 [Microcystis aeruginosa str. Chao 1910]
ATGAAAATTGTTACTGTTACTGAGGCCAAAGAACAAATTGATGAATTAGTGAATGATACCAATGATAATCATCAACCAAT
TTTGTTATCTGGTACGAAAAATAATGCTATTTTAATTGCTGAGGAAGATTGGAACTCTATTCAAGAAACGCTTTATTTGT
ATTCTATTCCTGGTATGGTAGATTCAATTATTGAAGGTGGCAACACTTCTATTGAAGATTGTCTGGATGAGGCGGGTATC
AGAGCAATTTTAAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References