Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1697709..1698328 Replicon chromosome
Accession NZ_CP073373
Organism Klebsiella sp. P1954

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KB890_RS08255 Protein ID WP_002892050.1
Coordinates 1698110..1698328 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KB890_RS08250 Protein ID WP_002892066.1
Coordinates 1697709..1698083 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB890_RS08240 (1692861) 1692861..1694054 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KB890_RS08245 (1694077) 1694077..1697223 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KB890_RS08250 (1697709) 1697709..1698083 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KB890_RS08255 (1698110) 1698110..1698328 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KB890_RS08260 (1698487) 1698487..1699053 + 567 WP_002892030.1 maltose O-acetyltransferase -
KB890_RS08265 (1699025) 1699025..1699165 - 141 WP_004147370.1 hypothetical protein -
KB890_RS08270 (1699186) 1699186..1699656 + 471 WP_002892026.1 YlaC family protein -
KB890_RS08275 (1699631) 1699631..1701082 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KB890_RS08280 (1701183) 1701183..1701881 + 699 WP_002892021.1 GNAT family protein -
KB890_RS08285 (1701878) 1701878..1702018 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KB890_RS08290 (1702018) 1702018..1702281 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T199786 WP_002892050.1 NZ_CP073373:1698110-1698328 [Klebsiella sp. P1954]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T199786 NZ_CP097576:889823-890029 [Microcystis aeruginosa str. Chao 1910]
ATGAGGAGTGCTTTAATAGATACTCATGTCTTTATCTGGTTAGCTGAGGATGACCCAATTTTGCCGGTTTCGCTGCGAGA
TAGTCTTGAAAATACCGATAATGTTTTTGTAAGTATTGCTAGTTTTTGGGAAATATCGATCAAGGTAAAAATTGGTAAAC
TCTCTCTCTGTTCTGAAATAACTATAACTCAAAAAGATTGGGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT199786 WP_002892066.1 NZ_CP073373:1697709-1698083 [Klebsiella sp. P1954]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT199786 NZ_CP097576:889620-889823 [Microcystis aeruginosa str. Chao 1910]
ATGCCCGATGCTCTCAAAACTGAACTTTTACATTATGCTGAATATTTGCTCACTAAGTCTGACCAAACAGAAGAAGATAA
ACCAGCAGCAAAAGAATCTGTAACTGTTAAAAGAACTTTAGCCGGTTCAATAAAAGGAACTTTCGTTTTACCTTTAGCTA
ATGACTTTGATGCTCCCTTAGAAGACTTTAAGGACTATAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References