Detailed information of TA system TA199783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1324083..1324718
• Replicon: chromosome
• Accession: NZ_CP073365
• Organism: Paenibacillus tritici strain PH55-1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A0E4H7G2
• Locus tag: KDC22_RS05625
• Protein ID: WP_019913013.1
• Coordinates: 1324368..1324718 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: KDC22_RS05620
• Protein ID: WP_036697455.1
• Coordinates: 1324083..1324364 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KDC22_RS05600 (KDC22_05600)	1319265..1319840	-	576	WP_173136427.1	TetR/AcrR family transcriptional regulator	-
KDC22_RS05605 (KDC22_05605)	1319993..1321192	+	1200	WP_211722339.1	MFS transporter	-
KDC22_RS05610 (KDC22_05610)	1321426..1322508	+	1083	WP_173136423.1	outer membrane lipoprotein carrier protein LolA	-
KDC22_RS05615 (KDC22_05615)	1322688..1323869	+	1182	WP_211722340.1	alanine racemase	-
KDC22_RS05620 (KDC22_05620)	1324083..1324364	+	282	WP_036697455.1	ribbon-helix-helix protein, CopG family	Antitoxin
KDC22_RS05625 (KDC22_05625)	1324368..1324718	+	351	WP_019913013.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KDC22_RS05630 (KDC22_05630)	1325126..1325734	+	609	WP_211722341.1	TetR/AcrR family transcriptional regulator	-
KDC22_RS05635 (KDC22_05635)	1325792..1327003	+	1212	WP_173136417.1	MFS transporter	-
KDC22_RS05640 (KDC22_05640)	1327647..1328939	+	1293	WP_211720874.1	group II intron reverse transcriptase/maturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12749.67 Da
• Isoelectric Point: 4.8265

>T199783 WP_019913013.1 NZ_CP073365:1324368-1324718 [Paenibacillus tritici]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKLVDDSLQISLGLIDF

Nucleotide

• Length: 351 bp

>T199783 NZ_CP097575:2930133-2930414 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10626.28 Da
• Isoelectric Point: 6.9804

>AT199783 WP_036697455.1 NZ_CP073365:1324083-1324364 [Paenibacillus tritici]
VANLQNTKRIMISLPDHLLQEVDGIVQLENSNRSELIRQAMKLYLSDRRKRTIRESMQRGYMEMAKINLTMACEAFLAEE
DADSTLGRLVSGV

Nucleotide

• Length: 282 bp

>AT199783 NZ_CP097575:2929909-2930136 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• AlphaFold DB: A0A0E4H7G2