Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3579952..3580570 Replicon chromosome
Accession NZ_CP073360
Organism Escherichia coli strain EC11

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KDN44_RS17210 Protein ID WP_001291435.1
Coordinates 3580352..3580570 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KDN44_RS17205 Protein ID WP_000344800.1
Coordinates 3579952..3580326 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDN44_RS17195 (3575041) 3575041..3576234 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KDN44_RS17200 (3576257) 3576257..3579406 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KDN44_RS17205 (3579952) 3579952..3580326 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KDN44_RS17210 (3580352) 3580352..3580570 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KDN44_RS17215 (3580741) 3580741..3581292 + 552 WP_000102578.1 maltose O-acetyltransferase -
KDN44_RS17220 (3581408) 3581408..3581878 + 471 WP_000136192.1 YlaC family protein -
KDN44_RS17225 (3582042) 3582042..3583592 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KDN44_RS17230 (3583634) 3583634..3583987 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KDN44_RS17240 (3584366) 3584366..3584677 + 312 WP_000409911.1 MGMT family protein -
KDN44_RS17245 (3584708) 3584708..3585280 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T199767 WP_001291435.1 NZ_CP073360:3580352-3580570 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T199767 NZ_CP097571:c2148499-2148290 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT199767 WP_000344800.1 NZ_CP073360:3579952-3580326 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT199767 NZ_CP097571:c2148804-2148511 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References