Detailed information of TA system TA199745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3679544..3680285
• Replicon: chromosome
• Accession: NZ_CP073356
• Organism: Proteus terrae subsp. cibarius strain SDQ8C180-2T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KDN45_RS16800
• Protein ID: WP_223672638.1
• Coordinates: 3679544..3679972 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KDN45_RS16805
• Protein ID: WP_075671318.1
• Coordinates: 3679965..3680285 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KDN45_RS16785 (KDN45_16700)	3675624..3676208	-	585	WP_075671324.1	DNA-3-methyladenine glycosylase I	-
KDN45_RS16790 (KDN45_16705)	3676447..3677352	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
KDN45_RS16795 (KDN45_16710)	3677362..3679434	+	2073	WP_075671322.1	glycine--tRNA ligase subunit beta	-
KDN45_RS16800 (KDN45_16715)	3679544..3679972	+	429	WP_223672638.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KDN45_RS16805 (KDN45_16720)	3679965..3680285	+	321	WP_075671318.1	helix-turn-helix domain-containing protein	Antitoxin
KDN45_RS16810 (KDN45_16725)	3680352..3680672	-	321	WP_075671316.1	hypothetical protein	-
KDN45_RS16815 (KDN45_16730)	3680778..3682064	-	1287	WP_075671314.1	DUF3748 domain-containing protein	-
KDN45_RS16820 (KDN45_16735)	3682201..3682818	+	618	WP_006534609.1	trimeric intracellular cation channel family protein	-
KDN45_RS16825 (KDN45_16740)	3683124..3683747	+	624	WP_006534608.1	guanylate kinase	-
KDN45_RS16830 (KDN45_16745)	3683802..3684077	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (15-139)

Antitoxin

• Cro/C1-type helix-turn-helix domain (50-96)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15862.55 Da
• Isoelectric Point: 10.1197

>T199745 WP_223672638.1 NZ_CP073356:3679544-3679972 [Proteus terrae subsp. cibarius]
VVKFTIVKTTTGEVMVIYKTKMFKNSFKKMPINDAALIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYK
QGSNLFFADGWKKSHLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Nucleotide

• Length: 429 bp

>T199745 NZ_CP097557:c149462-149181 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12068.99 Da
• Isoelectric Point: 10.0482

>AT199745 WP_075671318.1 NZ_CP073356:3679965-3680285 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Nucleotide

• Length: 321 bp

>AT199745 NZ_CP097557:c149686-149459 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA