Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3363700..3365447 Replicon chromosome
Accession NZ_CP073356
Organism Proteus terrae subsp. cibarius strain SDQ8C180-2T

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KDN45_RS15420 Protein ID WP_098941872.1
Coordinates 3363700..3365073 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KDN45_RS15425 Protein ID WP_098941871.1
Coordinates 3365070..3365447 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDN45_RS15405 (KDN45_15325) 3359372..3360355 - 984 WP_075673449.1 ABC transporter permease -
KDN45_RS15410 (KDN45_15330) 3360340..3361923 - 1584 WP_099659717.1 ABC transporter substrate-binding protein -
KDN45_RS15415 (KDN45_15335) 3362329..3363318 - 990 WP_099659718.1 glycosyltransferase -
KDN45_RS15420 (KDN45_15340) 3363700..3365073 + 1374 WP_098941872.1 HipA domain-containing protein Toxin
KDN45_RS15425 (KDN45_15345) 3365070..3365447 + 378 WP_098941871.1 helix-turn-helix transcriptional regulator Antitoxin
KDN45_RS15430 (KDN45_15350) 3365569..3366069 - 501 WP_075673444.1 hydrogenase maturation peptidase HycI -
KDN45_RS15435 (KDN45_15355) 3366066..3366476 - 411 WP_075673443.1 formate hydrogenlyase maturation HycH family protein -
KDN45_RS15440 (KDN45_15360) 3366469..3367251 - 783 WP_099659719.1 NADH-quinone oxidoreductase subunit B family protein -
KDN45_RS15445 (KDN45_15365) 3367248..3367802 - 555 WP_075673442.1 hydrogenase 4 subunit H -
KDN45_RS15450 (KDN45_15370) 3367814..3369547 - 1734 WP_075673441.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52589.44 Da        Isoelectric Point: 4.6415

>T199743 WP_098941872.1 NZ_CP073356:3363700-3365073 [Proteus terrae subsp. cibarius]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

>T199743 NZ_CP097556:c4471488-4470733 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14108.43 Da        Isoelectric Point: 10.5220

>AT199743 WP_098941871.1 NZ_CP073356:3365070-3365447 [Proteus terrae subsp. cibarius]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Download         Length: 378 bp

>AT199743 NZ_CP097556:c4471991-4471623 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGTTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References