Detailed information of TA system TA199742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3248088..3249810
• Replicon: chromosome
• Accession: NZ_CP073356
• Organism: Proteus terrae subsp. cibarius strain SDQ8C180-2T

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KDN45_RS14930
• Protein ID: WP_160230698.1
• Coordinates: 3248088..3249026 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A6I7DD21
• Locus tag: KDN45_RS14935
• Protein ID: WP_028870246.1
• Coordinates: 3249019..3249810 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KDN45_RS14910 (KDN45_14835)	3244029..3244541	-	513	WP_004249367.1	S26 family signal peptidase	-
KDN45_RS14915 (KDN45_14840)	3244525..3244872	-	348	WP_004249366.1	hypothetical protein	-
KDN45_RS14920 (KDN45_14845)	3244865..3247264	-	2400	WP_024008831.1	type IV secretion system protein TraC	-
KDN45_RS14925 (KDN45_14850)	3247264..3247956	-	693	WP_031500474.1	DsbC family protein	-
KDN45_RS14930 (KDN45_14855)	3248088..3249026	-	939	WP_160230698.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KDN45_RS14935 (KDN45_14860)	3249019..3249810	-	792	WP_028870246.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KDN45_RS14940 (KDN45_14865)	3250031..3250417	-	387	WP_000180225.1	TraA family conjugative transfer protein	-
KDN45_RS14945 (KDN45_14870)	3250414..3250986	-	573	WP_160230699.1	type IV conjugative transfer system lipoprotein TraV	-
KDN45_RS14950 (KDN45_14875)	3251061..3252350	-	1290	WP_156734091.1	TraB/VirB10 family protein	-
KDN45_RS14955 (KDN45_14880)	3252353..3253249	-	897	WP_108479663.1	type-F conjugative transfer system secretin TraK	-
KDN45_RS14960 (KDN45_14885)	3253233..3253859	-	627	WP_000667167.1	TraE/TraK family type IV conjugative transfer system protein	-
KDN45_RS14965 (KDN45_14890)	3253856..3254137	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	sul2 / tet(X6) / aph(4)-Ia / aac(3)-IVa / aph(3')-Ia	-	3211925..3299336	87411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35533.85 Da
• Isoelectric Point: 5.1171

>T199742 WP_160230698.1 NZ_CP073356:c3249026-3248088 [Proteus terrae subsp. cibarius]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAK

Nucleotide

• Length: 939 bp

>T199742 NZ_CP097556:3515699-3516277 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCTGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30085.43 Da
• Isoelectric Point: 9.5097

>AT199742 WP_028870246.1 NZ_CP073356:c3249810-3249019 [Proteus terrae subsp. cibarius]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT199742 NZ_CP097556:3515056-3515610 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCACCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A6I7DD21