Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4195847..4196466 Replicon chromosome
Accession NZ_CP073351
Organism Klebsiella pneumoniae strain CP19

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KBT94_RS20950 Protein ID WP_002892050.1
Coordinates 4196248..4196466 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KBT94_RS20945 Protein ID WP_002892066.1
Coordinates 4195847..4196221 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBT94_RS20935 4190999..4192192 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KBT94_RS20940 4192215..4195361 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
KBT94_RS20945 4195847..4196221 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KBT94_RS20950 4196248..4196466 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KBT94_RS20955 4196625..4197191 + 567 WP_002892030.1 maltose O-acetyltransferase -
KBT94_RS20960 4197163..4197303 - 141 WP_004147370.1 hypothetical protein -
KBT94_RS20965 4197324..4197794 + 471 WP_002892026.1 YlaC family protein -
KBT94_RS20970 4197769..4199220 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KBT94_RS20975 4199321..4200019 + 699 WP_002892021.1 GNAT family protein -
KBT94_RS20980 4200016..4200156 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KBT94_RS20985 4200156..4200419 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T199734 WP_002892050.1 NZ_CP073351:4196248-4196466 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T199734 NZ_CP097554:c5378432-5377776 [Klebsiella michiganensis]
ATGGCTTATGACTACAGCGCCAACCTCAACCCGGAAAAAGCCCTGATCTGGCGCATTGTCCATCGGGACAATATCCCATG
GATACTGGACAATGGCCTGCACTGCGGCAACAGCCAAGTGCAGGCTGAAAACTGGGTCAATATCGGCAACCCGGAGCTTA
TCGACAAACGCGCCGGGCATCCGGTGCCTGCCGGGACGGGCGGGACGCTGCATGACTATGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTATGCAGCGTCCCAACGAGGAAATCGTAATTCTGGT
CAGCAGCCTGCGACATGTGGCGGCGCAAAACGTCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAACTGGACCAACT
ACTACACCCGTCTGGACGACCTGAACCAGATTGACTGGCCGATGTTACAGGCGCGGGATTTCCGTCGCGATCCGGACGAT
CCAGCTAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGAAACATTGTCCAATCACACTGCTGAGTGGGATGGTTTG
TTACGATAACGACGTCAGGTTACAATTAGAACAATGGCTATTACAGCGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT199734 WP_002892066.1 NZ_CP073351:4195847-4196221 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT199734 NZ_CP097554:c5377779-5376712 [Klebsiella michiganensis]
ATGATGAAATATACACAAGGCAATTTACTGGATGCGCCCGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGACAATATGAAATCCTATGCCCTCGCCTGCAAACAAAAGC
AGGTCATGACCGGCAAGATGTTTATTACCGAAACCAGCGAACTAATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGAGTGGATCGAAGAAGGTTTGCAGGATCTGCGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCCATCGCTATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCAGACGTGCGGGCGCGGATTGAAT
CTGCGCTAGGTGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAACACC
GGCGTAAAAAAGCTTACTCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCAGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGTGCTATTGAACTGCACCAGCAGGAGGACGTTTTAAAGCTGC
GCTTTGAGGCGCACAATTACGGTCCCTTTTCCCCCAACCTGAACCATCTGCTTAATGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGCATCCCAGACAGCCAGCCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACGTCAACCTCTG
GCTGAATAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCACCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACCCGAGGAGAATGCCAGCCCACTCTGGATTCAGTAAAAGAGGGG
CTACACCAGTGGCCTGCCGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTGTTTGATGATCATCATCTTCAATTCGCCAT
AAACCGTGTGATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References