Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873302..873956 Replicon chromosome
Accession NZ_CP073351
Organism Klebsiella pneumoniae strain CP19

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag KBT94_RS04410 Protein ID WP_004144731.1
Coordinates 873549..873956 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KBT94_RS04405 Protein ID WP_002916312.1
Coordinates 873302..873568 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBT94_RS04380 868458..869891 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KBT94_RS04385 870010..870738 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KBT94_RS04390 870788..871099 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KBT94_RS04395 871263..871922 + 660 WP_002916317.1 hemolysin III family protein -
KBT94_RS04400 872073..873056 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KBT94_RS04405 873302..873568 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KBT94_RS04410 873549..873956 + 408 WP_004144731.1 protein YgfX Toxin
KBT94_RS04415 873963..874484 - 522 WP_002916308.1 flavodoxin FldB -
KBT94_RS04420 874585..875481 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KBT94_RS04425 875504..876217 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KBT94_RS04430 876223..877956 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T199724 WP_004144731.1 NZ_CP073351:873549-873956 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T199724 NZ_CP097550:91822-92217 [Dinoroseobacter shibae]
ATGAGCGCTGAATTCGCAGACACGAATGTTGTGCTCTACCTGCTCGACGATGGTCCAAAGGCTGAGAGGGCGGAGGAAAT
TCTGGGGCAGGGACCCCGGATCAGCGTTCAGGTCCTGAACGAAGCGATGGTCAATTGCCGACGGAAAGCTGGGCTCAGTT
GGGAAGATACCGGAGCGTTTCTTGAGGGTATTACGTCCGTATGCCCTGTCGAGGGCCTAACGGTTCAAACCCATCAAGTC
GGTCGCGCGTTGGCAGAGAAGTACCAGTTATCGGTCTATGACGCGATGATCGTGTCTGCCGCGCTGATCGCTGGGTGCAC
GACTTTGTGGACTGAGGACATGCACGACGGATTGCTGGTCGAGGATCGGCTGCGCATCGTCAATCCATTTGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT199724 WP_002916312.1 NZ_CP073351:873302-873568 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT199724 NZ_CP097550:91605-91832 [Dinoroseobacter shibae]
ATGCAAGTTGCCAAATGGGGAAACTCCCTTGCCGTCCGGCTACCCGCGGATCTTGTGAGGGAACTCGGCTTAAAGGAAGG
CGATCAGGTCGACCTGGTAAAGGACGATGGAACCATTCTTGTGAGACGCCAACCTCGCGCCGATGAAGTTCTACAAGGGC
TGAGGCGGTTTCGCAGAAAACTGCCCAAGGATGCGCGTCTAAGCCGCGACGCCGCGCATGAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References