Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1624242..1624878 Replicon chromosome
Accession NZ_CP073315
Organism Psychrobacillus sp. INOP01

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KD050_RS08170 Protein ID WP_211895677.1
Coordinates 1624242..1624592 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KD050_RS08175 Protein ID WP_235753945.1
Coordinates 1624597..1624878 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KD050_RS08135 (KD050_08135) 1619682..1620467 - 786 WP_211895671.1 RNA polymerase sigma factor SigB -
KD050_RS08140 (KD050_08140) 1620445..1620915 - 471 WP_211895672.1 anti-sigma B factor RsbW -
KD050_RS08145 (KD050_08145) 1620902..1621249 - 348 WP_211895673.1 anti-sigma factor antagonist -
KD050_RS08150 (KD050_08150) 1621317..1622315 - 999 WP_211895674.1 PP2C family protein-serine/threonine phosphatase -
KD050_RS08155 (KD050_08155) 1622332..1622733 - 402 WP_211895675.1 anti-sigma regulatory factor -
KD050_RS08160 (KD050_08160) 1622739..1623104 - 366 WP_211896244.1 STAS domain-containing protein -
KD050_RS08165 (KD050_08165) 1623101..1623928 - 828 WP_211895676.1 STAS domain-containing protein -
KD050_RS08170 (KD050_08170) 1624242..1624592 - 351 WP_211895677.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KD050_RS08175 (KD050_08175) 1624597..1624878 - 282 WP_235753945.1 transcriptional regulator Antitoxin
KD050_RS08180 (KD050_08180) 1625012..1626118 - 1107 WP_211895679.1 alanine racemase -
KD050_RS08185 (KD050_08185) 1626185..1627210 - 1026 WP_211895680.1 outer membrane lipoprotein carrier protein LolA -
KD050_RS08190 (KD050_08190) 1627269..1627622 - 354 WP_211895681.1 holo-ACP synthase -
KD050_RS08195 (KD050_08195) 1627691..1628317 + 627 WP_211895682.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12854.85 Da        Isoelectric Point: 5.6262

>T199710 WP_211895677.1 NZ_CP073315:c1624592-1624242 [Psychrobacillus sp. INOP01]
MIVKRGDVFFADLSPVIGSEQGGTRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKEYDFERDSVILLEQL
RTIDKSRLTDKITHLDVDVMENVDHALGISLGIVKF

Download         Length: 351 bp

>T199710 NZ_CP097528:4691353-4691928 [Pseudomonas putida]
ATGAAGCACTCGCCCTTCACGGCCATATACGACGCGAATGTACTTTACCCTGCTCCACTGCGTGATTTCCTGATGAACCT
AGCGCTGACGGGCATCTACCGGGCACGTTGGTCAGCGAGCATTCATGACGAGTGGAAGCGCAATCTGCTACTCAACCGAC
CTGACCTCACGCCTGAACATTTGGATCGCACGTCATCGCTGATGGATGCTGCGGTGCCTGATGCACTCGTCACTGACTAC
GATTCACTGGTCGAAGGGCTGGACTTGCCAGATAGGGATGATCGACATGTTCTCGCAGCTGCAATCAAGTGCAACGCTTC
GGTCATCGTCACCTTCAATTTGAAGGATTTTTCCAAGGCGGTTCTTGGTGCCTTCGATATTGAACCCTTGCATCCGGACG
ACTTCATCGCTGACCTTTGGGACCTGGACAAGGCAGCAGTCCTCGAAGCTGCCCAGCGGCAGCGAATATCGCTGAAGAAC
CCACCGCACAGCGTACAGCAGTATCTCGACAGGCTGCTTCAGCAGAAGCTTCCCGAGACAGTGAAACTGCTTTCAGCATT
CAAGTTCCTCCTCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10398.94 Da        Isoelectric Point: 7.3216

>AT199710 WP_235753945.1 NZ_CP073315:c1624878-1624597 [Psychrobacillus sp. INOP01]
VVSDKKKKEAIIQLPHQLVNEGVKTVKQSLTGVESFVRVQANEYIKNGQANLIREAMMKGYVEMSHINLSICTECLHAEY
EAQHTTERLVSGG

Download         Length: 282 bp

>AT199710 NZ_CP097528:4690889-4691356 [Pseudomonas putida]
ATGACCACCGCCAACCTCTCTAGCCATGTGCTTCCTGACGAGAAAGAAATTGCCGTGGCAGTCGAGTCAAGCCGCACGCT
GGCAGCGTTCCTCTCGACAAAATCAGATACCCAACGGATCGAACTGCTCAACGAGGAAAATCAGCGCCAGGTTGTTGAAG
TACCTACTTTCGCCCTACGCCTATTCGGCGAAATTCTCAGCGAACTGGCCTTGGGTAACTCAGTCAAAGTCGTTCCAATC
CACGCCGAACTAACTACCCAGGAAGCAGCAGACCTGCTTAACGTCTCCCGGCCGCACTTGGTAAAGCTGCTCGACGAAGC
GGTGATTCCGCACACCAAGACAGGCCGCCATCGTCGTGTCAAATTCTCAGACCTGGTTGCCTACAAGGACAAACGTGATG
GGGTGAGCCGCGCTGCGATAGATGCGCTGGCAGCCCAAGCTCAGGAATTGAAGATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References