199707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 4770637..4772420 Replicon chromosome
Accession NZ_CP073310
Organism Enterobacter cloacae strain CZ862

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KDU74_RS23450 Protein ID WP_178327526.1
Coordinates 4771071..4772420 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KDU74_RS23445 Protein ID WP_178327527.1
Coordinates 4770637..4771074 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDU74_RS23425 (KDU74_23425) 4766703..4767962 + 1260 Protein_4598 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
KDU74_RS23435 (KDU74_23435) 4769296..4769559 + 264 Protein_4600 sugar ABC transporter ATP-binding protein -
KDU74_RS23440 (KDU74_23440) 4769575..4770585 + 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
KDU74_RS23445 (KDU74_23445) 4770637..4771074 - 438 WP_178327527.1 helix-turn-helix transcriptional regulator Antitoxin
KDU74_RS23450 (KDU74_23450) 4771071..4772420 - 1350 WP_178327526.1 HipA domain-containing protein Toxin
KDU74_RS23455 (KDU74_23455) 4772555..4773268 - 714 WP_178327525.1 outer membrane permeability protein SanA -
KDU74_RS23460 (KDU74_23460) 4773396..4774280 - 885 WP_178327524.1 cytidine deaminase -
KDU74_RS23465 (KDU74_23465) 4774410..4775105 - 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
KDU74_RS23470 (KDU74_23470) 4775102..4775500 - 399 WP_023619766.1 CidA/LrgA family protein -
KDU74_RS23475 (KDU74_23475) 4775668..4776600 + 933 WP_013097946.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51179.72 Da        Isoelectric Point: 4.5348

>T199707 WP_178327526.1 NZ_CP073310:c4772420-4771071 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVSDVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPIYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIELPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

>T199707 NZ_CP097528:2780716-2781153 [Pseudomonas putida]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGCGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGTCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCTGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCTACCACCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCTCAGCCTGAGTTGACCCGAACGCTGGGCAATCGCTTTCTGGATGACTGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACGCCGGACAGCCGCCTGTTCTAG

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16168.67 Da        Isoelectric Point: 10.8665

>AT199707 WP_178327527.1 NZ_CP073310:c4771074-4770637 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDGDPDKSSVVKRQRVSSGLTRISTLHRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp

>AT199707 NZ_CP097528:2780270-2780719 [Pseudomonas putida]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCCTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGCGATTTCGAAATCCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGTGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCCGTGTTCGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAACGCTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References