Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 1870975..1871633 | Replicon | chromosome |
| Accession | NZ_CP073310 | ||
| Organism | Enterobacter cloacae strain CZ862 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | - |
| Locus tag | KDU74_RS09235 | Protein ID | WP_178328621.1 |
| Coordinates | 1871313..1871633 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A851GDW8 |
| Locus tag | KDU74_RS09230 | Protein ID | WP_045333995.1 |
| Coordinates | 1870975..1871292 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KDU74_RS09190 (KDU74_09190) | 1866809..1867789 | - | 981 | WP_211944394.1 | IS5-like element ISKpn26 family transposase | - |
| KDU74_RS09195 (KDU74_09195) | 1867860..1868252 | + | 393 | Protein_1821 | transcriptional regulator | - |
| KDU74_RS09200 (KDU74_09200) | 1868249..1868863 | + | 615 | WP_178328625.1 | hypothetical protein | - |
| KDU74_RS09205 (KDU74_09205) | 1868953..1869363 | + | 411 | WP_178328624.1 | hypothetical protein | - |
| KDU74_RS09210 (KDU74_09210) | 1869441..1869680 | + | 240 | WP_178328623.1 | DUF905 domain-containing protein | - |
| KDU74_RS09215 (KDU74_09215) | 1869776..1870234 | + | 459 | WP_178328622.1 | antirestriction protein | - |
| KDU74_RS09220 (KDU74_09220) | 1870250..1870726 | + | 477 | WP_045333998.1 | RadC family protein | - |
| KDU74_RS09225 (KDU74_09225) | 1870735..1870956 | + | 222 | WP_021520981.1 | DUF987 domain-containing protein | - |
| KDU74_RS09230 (KDU74_09230) | 1870975..1871292 | + | 318 | WP_045333995.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KDU74_RS09235 (KDU74_09235) | 1871313..1871633 | + | 321 | WP_178328621.1 | TA system toxin CbtA family protein | Toxin |
| KDU74_RS09240 (KDU74_09240) | 1871933..1872790 | - | 858 | WP_178328620.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| KDU74_RS09245 (KDU74_09245) | 1872921..1873871 | - | 951 | WP_001581454.1 | D-ribose ABC transporter substrate-binding protein | - |
| KDU74_RS09250 (KDU74_09250) | 1873960..1875021 | - | 1062 | WP_001581452.1 | ABC transporter permease | - |
| KDU74_RS09255 (KDU74_09255) | 1875045..1876583 | - | 1539 | WP_032637388.1 | sugar ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1856113..1871633 | 15520 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12198.22 Da Isoelectric Point: 7.2776
>T199701 WP_178328621.1 NZ_CP073310:1871313-1871633 [Enterobacter cloacae]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSHFITAVDILKARRAMREMRI
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSHFITAVDILKARRAMREMRI
Download Length: 321 bp
>T199701 NZ_CP097527:4691350-4691925 [Pseudomonas putida]
ATGAAGCACTCGCCCTTCACGGCCATATACGACGCGAATGTACTTTACCCTGCTCCACTGCGTGATTTCCTGATGAACCT
AGCGCTGACGGGCATCTACCGGGCACGTTGGTCAGCGAGCATTCATGACGAGTGGAAGCGCAATCTGCTACTCAACCGAC
CTGACCTCACGCCTGAACATTTGGATCGCACGTCATCGCTGATGGATGCTGCGGTGCCTGATGCACTCGTCACTGACTAC
GATTCACTGGTCGAAGGGCTGGACTTGCCAGATAGGGATGATCGACATGTTCTCGCAGCTGCAATCAAGTGCAACGCTTC
GGTCATCGTCACCTTCAATTTGAAGGATTTTTCCAAGGCGGTTCTTGGTGCCTTCGATATTGAACCCTTGCATCCGGACG
ACTTCATCGCTGACCTTTGGGACCTGGACAAGGCAGCAGTCCTCGAAGCTGCCCAGCGGCAGCGAATATCGCTGAAGAAC
CCACCGCACAGCGTACAGCAGTATCTCGACAGGCTGCTTCAGCAGAAGCTTCCCGAGACAGTGAAACTGCTTTCAGCATT
CAAGTTCCTCCTCTGA
ATGAAGCACTCGCCCTTCACGGCCATATACGACGCGAATGTACTTTACCCTGCTCCACTGCGTGATTTCCTGATGAACCT
AGCGCTGACGGGCATCTACCGGGCACGTTGGTCAGCGAGCATTCATGACGAGTGGAAGCGCAATCTGCTACTCAACCGAC
CTGACCTCACGCCTGAACATTTGGATCGCACGTCATCGCTGATGGATGCTGCGGTGCCTGATGCACTCGTCACTGACTAC
GATTCACTGGTCGAAGGGCTGGACTTGCCAGATAGGGATGATCGACATGTTCTCGCAGCTGCAATCAAGTGCAACGCTTC
GGTCATCGTCACCTTCAATTTGAAGGATTTTTCCAAGGCGGTTCTTGGTGCCTTCGATATTGAACCCTTGCATCCGGACG
ACTTCATCGCTGACCTTTGGGACCTGGACAAGGCAGCAGTCCTCGAAGCTGCCCAGCGGCAGCGAATATCGCTGAAGAAC
CCACCGCACAGCGTACAGCAGTATCTCGACAGGCTGCTTCAGCAGAAGCTTCCCGAGACAGTGAAACTGCTTTCAGCATT
CAAGTTCCTCCTCTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 12094.70 Da Isoelectric Point: 6.9467
>AT199701 WP_045333995.1 NZ_CP073310:1870975-1871292 [Enterobacter cloacae]
MRNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYIYITVYPTQR
MRNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYIYITVYPTQR
Download Length: 318 bp
>AT199701 NZ_CP097527:4690886-4691353 [Pseudomonas putida]
ATGACCACCGCCAACCTCTCTAGCCATGTGCTTCCTGACGAGAAAGAAATTGCCGTGGCAGTCGAGTCAAGCCGCACGCT
GGCAGCGTTCCTCTCGACAAAATCAGATACCCAACGGATCGAACTGCTCAACGAGGAAAATCAGCGCCAGGTTGTTGAAG
TACCTACTTTCGCCCTACGCCTATTCGGCGAAATTCTCAGCGAACTGGCCTTGGGTAACTCAGTCAAAGTCGTTCCAATC
CACGCCGAACTAACTACCCAGGAAGCAGCAGACCTGCTTAACGTCTCCCGGCCGCACTTGGTAAAGCTGCTCGACGAAGC
GGTGATTCCGCACACCAAGACAGGCCGCCATCGTCGTGTCAAATTCTCAGACCTGGTTGCCTACAAGGACAAACGTGATG
GGGTGAGCCGCGCTGCGATAGATGCGCTGGCAGCCCAAGCTCAGGAATTGAAGATGGGGTACGAATGA
ATGACCACCGCCAACCTCTCTAGCCATGTGCTTCCTGACGAGAAAGAAATTGCCGTGGCAGTCGAGTCAAGCCGCACGCT
GGCAGCGTTCCTCTCGACAAAATCAGATACCCAACGGATCGAACTGCTCAACGAGGAAAATCAGCGCCAGGTTGTTGAAG
TACCTACTTTCGCCCTACGCCTATTCGGCGAAATTCTCAGCGAACTGGCCTTGGGTAACTCAGTCAAAGTCGTTCCAATC
CACGCCGAACTAACTACCCAGGAAGCAGCAGACCTGCTTAACGTCTCCCGGCCGCACTTGGTAAAGCTGCTCGACGAAGC
GGTGATTCCGCACACCAAGACAGGCCGCCATCGTCGTGTCAAATTCTCAGACCTGGTTGCCTACAAGGACAAACGTGATG
GGGTGAGCCGCGCTGCGATAGATGCGCTGGCAGCCCAAGCTCAGGAATTGAAGATGGGGTACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|