Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 31914..32440 | Replicon | chromosome |
| Accession | NZ_CP073310 | ||
| Organism | Enterobacter cloacae strain CZ862 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KDU74_RS00170 | Protein ID | WP_000323025.1 |
| Coordinates | 32153..32440 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | J5W3H0 |
| Locus tag | KDU74_RS00165 | Protein ID | WP_004196370.1 |
| Coordinates | 31914..32153 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KDU74_RS00135 (KDU74_00135) | 27251..27443 | - | 193 | Protein_27 | MFS transporter | - |
| KDU74_RS00140 (KDU74_00140) | 27473..28450 | + | 978 | WP_004196334.1 | chromate resistance protein | - |
| KDU74_RS00145 (KDU74_00145) | 28407..29783 | + | 1377 | WP_004196363.1 | chromate efflux transporter | - |
| KDU74_RS00150 (KDU74_00150) | 29814..30503 | - | 690 | WP_004196322.1 | hypothetical protein | - |
| KDU74_RS00155 (KDU74_00155) | 30517..31254 | - | 738 | WP_008460272.1 | HupE/UreJ family protein | - |
| KDU74_RS00160 (KDU74_00160) | 31298..31663 | - | 366 | WP_009651956.1 | hypothetical protein | - |
| KDU74_RS27125 | 31791..31889 | - | 99 | Protein_33 | protein YdfV | - |
| KDU74_RS00165 (KDU74_00165) | 31914..32153 | + | 240 | WP_004196370.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KDU74_RS00170 (KDU74_00170) | 32153..32440 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KDU74_RS00175 (KDU74_00175) | 32512..32670 | + | 159 | WP_013087178.1 | type I toxin-antitoxin system Hok family toxin | - |
| KDU74_RS00180 (KDU74_00180) | 33546..33860 | + | 315 | WP_023338051.1 | hypothetical protein | - |
| KDU74_RS00185 (KDU74_00185) | 33969..34127 | + | 159 | WP_223826502.1 | hypothetical protein | - |
| KDU74_RS00190 (KDU74_00190) | 34205..34561 | + | 357 | WP_249166284.1 | hypothetical protein | - |
| KDU74_RS00195 (KDU74_00195) | 34743..34943 | + | 201 | WP_031494497.1 | hypothetical protein | - |
| KDU74_RS00200 (KDU74_00200) | 34984..35775 | + | 792 | WP_180266963.1 | N-6 DNA methylase | - |
| KDU74_RS00205 (KDU74_00205) | 35818..36153 | + | 336 | WP_023345479.1 | hypothetical protein | - |
| KDU74_RS00210 (KDU74_00210) | 36842..37135 | + | 294 | WP_032663725.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T199691 WP_000323025.1 NZ_CP073310:32153-32440 [Enterobacter cloacae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T199691 NZ_CP097519:938662-938841 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9018.43 Da Isoelectric Point: 4.3894
>AT199691 WP_004196370.1 NZ_CP073310:31914-32153 [Enterobacter cloacae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
Download Length: 240 bp
>AT199691 NZ_CP097519:938039-938638 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAACCTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAACCTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|