Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4934578..4935094 Replicon chromosome
Accession NZ_CP073302
Organism Klebsiella pneumoniae strain SW1780

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KCX81_RS24395 Protein ID WP_002886902.1
Coordinates 4934578..4934862 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KCX81_RS24400 Protein ID WP_002886901.1
Coordinates 4934852..4935094 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCX81_RS24370 (KCX81_24370) 4930062..4930325 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KCX81_RS24375 (KCX81_24375) 4930455..4930628 + 174 WP_002886906.1 hypothetical protein -
KCX81_RS24380 (KCX81_24380) 4930631..4931374 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KCX81_RS24385 (KCX81_24385) 4931731..4933869 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KCX81_RS24390 (KCX81_24390) 4934110..4934574 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KCX81_RS24395 (KCX81_24395) 4934578..4934862 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KCX81_RS24400 (KCX81_24400) 4934852..4935094 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KCX81_RS24405 (KCX81_24405) 4935172..4937082 - 1911 WP_004152270.1 PRD domain-containing protein -
KCX81_RS24410 (KCX81_24410) 4937105..4938259 - 1155 WP_002886900.1 lactonase family protein -
KCX81_RS24415 (KCX81_24415) 4938325..4939065 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T199681 WP_002886902.1 NZ_CP073302:c4934862-4934578 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T199681 NZ_CP097512:857246-857455 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT199681 WP_002886901.1 NZ_CP073302:c4935094-4934852 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT199681 NZ_CP097512:856946-857239 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References