199679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4217395..4218014 Replicon chromosome
Accession NZ_CP073302
Organism Klebsiella pneumoniae strain SW1780

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KCX81_RS20965 Protein ID WP_002892050.1
Coordinates 4217796..4218014 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KCX81_RS20960 Protein ID WP_002892066.1
Coordinates 4217395..4217769 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCX81_RS20950 (KCX81_20950) 4212547..4213740 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KCX81_RS20955 (KCX81_20955) 4213763..4216909 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
KCX81_RS20960 (KCX81_20960) 4217395..4217769 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KCX81_RS20965 (KCX81_20965) 4217796..4218014 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KCX81_RS20970 (KCX81_20970) 4218173..4218739 + 567 WP_002892030.1 maltose O-acetyltransferase -
KCX81_RS20975 (KCX81_20975) 4218711..4218851 - 141 WP_004147370.1 hypothetical protein -
KCX81_RS20980 (KCX81_20980) 4218872..4219342 + 471 WP_002892026.1 YlaC family protein -
KCX81_RS20985 (KCX81_20985) 4219317..4220768 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KCX81_RS20990 (KCX81_20990) 4220869..4221567 + 699 WP_002892021.1 GNAT family protein -
KCX81_RS20995 (KCX81_20995) 4221564..4221704 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KCX81_RS21000 (KCX81_21000) 4221704..4221967 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T199679 WP_002892050.1 NZ_CP073302:4217796-4218014 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T199679 NZ_CP097491:73779-74156 [Pseudomonas sp. BYT-5]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT199679 WP_002892066.1 NZ_CP073302:4217395-4217769 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT199679 NZ_CP097491:74137-74472 [Pseudomonas sp. BYT-5]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References