Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 102318..103228 Replicon plasmid pVir_030925
Accession NZ_CP073286
Organism Klebsiella pneumoniae subsp. ozaenae strain WCHKP030925

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag CLQ62_RS26885 Protein ID WP_004026354.1
Coordinates 102318..102788 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag CLQ62_RS26890 Protein ID WP_004026357.1
Coordinates 102785..103228 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ62_RS26865 (CLQ62_26845) 97730..98128 - 399 WP_102010073.1 H-NS family nucleoid-associated regulatory protein -
CLQ62_RS26870 (CLQ62_26850) 98465..98959 - 495 WP_004212794.1 thermonuclease family protein -
CLQ62_RS27730 99137..99403 + 267 WP_223175074.1 DUF1173 family protein -
CLQ62_RS26875 (CLQ62_26855) 99436..100086 + 651 WP_068893702.1 DUF1173 family protein -
CLQ62_RS26885 (CLQ62_26865) 102318..102788 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
CLQ62_RS26890 (CLQ62_26870) 102785..103228 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
CLQ62_RS26895 (CLQ62_26875) 103329..103832 - 504 Protein_112 DUF4113 domain-containing protein -
CLQ62_RS26900 (CLQ62_26880) 103930..104151 - 222 WP_004213643.1 DUF2188 domain-containing protein -
CLQ62_RS26905 (CLQ62_26885) 104332..104451 - 120 Protein_114 Fe3+-citrate ABC transporter substrate-binding protein -
CLQ62_RS26910 (CLQ62_26890) 104526..106652 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
CLQ62_RS26915 (CLQ62_26895) 106739..107692 - 954 Protein_116 fec operon regulator FecR -
CLQ62_RS26920 (CLQ62_26900) 107689..108210 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..228949 228949
- flank IS/Tn - - 101472..101975 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T199664 WP_004026354.1 NZ_CP073286:c102788-102318 [Klebsiella pneumoniae subsp. ozaenae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T199664 NZ_CP097463:559246-559683 [Jatrophihabitans sp. SB3-54]
GTGACCGCTGCGGAGACGCGGCGCTGGCTCATCGACAAGTCAGCGCTCGTTCGTCTGAGTGAGAGCCTGGACGCGTCAGA
GTGGATCTCTCGTATTGATCGAGGACTCGTGCGGATCGCCACTGTCACGATCCTGGAGGTCGGATTCTCCGCGAGATCGG
CAGATGATCTTCGAGCCAAATTGCGTAGACCGCCTGTCGCTGCGATGCCTATCGAGAACGCGACTCCTAGAATCGAGACA
CGCGCCATCGAGGTCCAAGAATCGCTCGCGGGGCTCGGACATCACCGGGCGCCATCCGTTCCAGATCTGATCATCGCCGC
GATCGCTGAACTGGCTGGGCTGGTGGTGCTTCATGTCGACAAGGATTTCGAGCTAATCGCCGGCGTGACCCAGCAGCCAA
CCGAACGACTCCGGCTCGCACAGCCACACTCGACCTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT199664 WP_004026357.1 NZ_CP073286:c103228-102785 [Klebsiella pneumoniae subsp. ozaenae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT199664 NZ_CP097463:559028-559249 [Jatrophihabitans sp. SB3-54]
ATGTCAGATGTGCTGATTCGCGACGTGCCCGATGACGTCCTTGCGGCGGTCGAGTCGCATGCAACGAAGCTCGGGCTGTC
GCGCAACGAGTACCTGCGTCGCCAGCTCGCACAGGACGCGATGCGGTCGACCGTGCCCGTCACGATGGACGACCTGCGGT
GGTTCACCCAGACATTCAGCGATCTCGCTGAGTCAGAGGTCATGCGGCAGGCGTGGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References