Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4923343..4923859 Replicon chromosome
Accession NZ_CP073285
Organism Klebsiella pneumoniae subsp. ozaenae strain WCHKP030925

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag CLQ62_RS23740 Protein ID WP_004178374.1
Coordinates 4923343..4923627 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CLQ62_RS23745 Protein ID WP_002886901.1
Coordinates 4923617..4923859 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ62_RS23715 (4918739) 4918739..4919002 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
CLQ62_RS23720 (4919132) 4919132..4919305 + 174 WP_041169004.1 hypothetical protein -
CLQ62_RS23725 (4919308) 4919308..4920051 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CLQ62_RS23730 (4920408) 4920408..4922546 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CLQ62_RS23735 (4922875) 4922875..4923339 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CLQ62_RS23740 (4923343) 4923343..4923627 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLQ62_RS23745 (4923617) 4923617..4923859 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CLQ62_RS23750 (4923937) 4923937..4925847 - 1911 WP_012737231.1 PRD domain-containing protein -
CLQ62_RS23755 (4925870) 4925870..4927024 - 1155 WP_012737230.1 lactonase family protein -
CLQ62_RS23760 (4927091) 4927091..4927831 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T199661 WP_004178374.1 NZ_CP073285:c4923627-4923343 [Klebsiella pneumoniae subsp. ozaenae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T199661 NZ_CP097430:c4251366-4251193 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT199661 WP_002886901.1 NZ_CP073285:c4923859-4923617 [Klebsiella pneumoniae subsp. ozaenae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT199661 NZ_CP097430:c4251690-4251394 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References