Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/RelB(antitoxin) |
| Location | 1279387..1280026 | Replicon | chromosome |
| Accession | NZ_CP073283 | ||
| Organism | Bifidobacterium longum subsp. infantis strain BINF | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | KDJ92_RS06070 | Protein ID | WP_212105396.1 |
| Coordinates | 1279670..1280026 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | KDJ92_RS06065 | Protein ID | WP_003829235.1 |
| Coordinates | 1279387..1279683 (+) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KDJ92_RS06040 (KDJ92_06040) | 1274778..1277456 | - | 2679 | WP_212105390.1 | alanine--tRNA ligase | - |
| KDJ92_RS06045 (KDJ92_06045) | 1277585..1277821 | - | 237 | WP_029679572.1 | hypothetical protein | - |
| KDJ92_RS06050 (KDJ92_06050) | 1277821..1278219 | - | 399 | WP_012577919.1 | DUF948 domain-containing protein | - |
| KDJ92_RS06055 (KDJ92_06055) | 1278302..1278976 | - | 675 | WP_212105393.1 | histidine phosphatase family protein | - |
| KDJ92_RS06060 (KDJ92_06060) | 1279052..1279240 | + | 189 | WP_234933089.1 | hypothetical protein | - |
| KDJ92_RS06065 (KDJ92_06065) | 1279387..1279683 | + | 297 | WP_003829235.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KDJ92_RS06070 (KDJ92_06070) | 1279670..1280026 | + | 357 | WP_212105396.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KDJ92_RS12900 | 1280203..1280448 | - | 246 | WP_234933090.1 | hypothetical protein | - |
| KDJ92_RS12905 | 1280484..1280819 | - | 336 | WP_234933091.1 | transglutaminase family protein | - |
| KDJ92_RS06080 (KDJ92_06080) | 1280924..1281199 | - | 276 | WP_234933092.1 | SdpI family protein | - |
| KDJ92_RS06085 (KDJ92_06085) | 1281174..1281563 | + | 390 | WP_234933093.1 | cytidine deaminase | - |
| KDJ92_RS06090 (KDJ92_06090) | 1281701..1282483 | + | 783 | WP_212105399.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| KDJ92_RS06095 (KDJ92_06095) | 1282821..1283447 | - | 627 | WP_007052130.1 | 30S ribosomal protein S4 | - |
| KDJ92_RS06100 (KDJ92_06100) | 1283646..1284638 | - | 993 | WP_212105402.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13315.26 Da Isoelectric Point: 7.9984
>T199643 WP_212105396.1 NZ_CP073283:1279670-1280026 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNHPSVILQWDDGTRIALMTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA
MMKTDPRQFEIWWVPFAFPDKPGKAKNHPSVILQWDDGTRIALMTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA
Download Length: 357 bp
>T199643 NZ_CP097430:c605390-604926 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 99 a.a. Molecular weight: 10997.50 Da Isoelectric Point: 4.2896
>AT199643 WP_003829235.1 NZ_CP073283:1279387-1279683 [Bifidobacterium longum subsp. infantis]
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED
Download Length: 297 bp
>AT199643 NZ_CP097430:c605725-605390 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|