Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 816929..817782 Replicon chromosome
Accession NZ_CP073283
Organism Bifidobacterium longum subsp. infantis strain BINF

Toxin (Protein)


Gene name relE Uniprot ID D6ZUU6
Locus tag KDJ92_RS03775 Protein ID WP_013140895.1
Coordinates 817291..817782 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag KDJ92_RS03770 Protein ID WP_011068030.1
Coordinates 816929..817291 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDJ92_RS03765 (KDJ92_03765) 814084..816783 + 2700 WP_212104897.1 aconitate hydratase AcnA -
KDJ92_RS03770 (KDJ92_03770) 816929..817291 + 363 WP_011068030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KDJ92_RS03775 (KDJ92_03775) 817291..817782 + 492 WP_013140895.1 PIN domain-containing protein Toxin
KDJ92_RS03780 (KDJ92_03780) 817842..819947 - 2106 WP_013140894.1 DUF262 domain-containing protein -
KDJ92_RS03785 (KDJ92_03785) 820036..820677 - 642 WP_077425506.1 GNAT family N-acetyltransferase -
KDJ92_RS03790 (KDJ92_03790) 820718..820858 - 141 Protein_744 LuxR C-terminal-related transcriptional regulator -
KDJ92_RS03795 (KDJ92_03795) 821142..822044 + 903 WP_212104901.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18314.88 Da        Isoelectric Point: 4.5590

>T199642 WP_013140895.1 NZ_CP073283:817291-817782 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T199642 NZ_CP097430:183506-183613 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT199642 WP_011068030.1 NZ_CP073283:816929-817291 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp

>AT199642 NZ_CP097430:c183458-183392 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A564VMG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2W1N3

References