Detailed information of TA system TA199640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1550452..1551689
• Replicon: chromosome
• Accession: NZ_CP073275
• Organism: Streptococcus equi subsp. zooepidemicus strain IN-6992

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: KCL43_RS07320
• Protein ID: WP_165623639.1
• Coordinates: 1550452..1551213 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: KCL43_RS07325
• Protein ID: WP_165623640.1
• Coordinates: 1551213..1551689 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCL43_RS07300 (KCL43_07300)	1546472..1546864	-	393	Protein_1419	relaxase/mobilization nuclease domain-containing protein	-
KCL43_RS07305 (KCL43_07305)	1546851..1547216	-	366	WP_012678608.1	plasmid mobilization relaxosome protein MobC	-
KCL43_RS07310 (KCL43_07310)	1547226..1547585	-	360	WP_165623491.1	SAG1252 family conjugative relaxosome accessory protein	-
KCL43_RS07315 (KCL43_07315)	1547903..1550410	-	2508	WP_206157586.1	AAA family ATPase	-
KCL43_RS07320 (KCL43_07320)	1550452..1551213	-	762	WP_165623639.1	type II toxin-antitoxin system toxin PezT	Toxin
KCL43_RS07325 (KCL43_07325)	1551213..1551689	-	477	WP_165623640.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
KCL43_RS07330 (KCL43_07330)	1551759..1552046	-	288	WP_165623641.1	hypothetical protein	-
KCL43_RS07335 (KCL43_07335)	1552091..1552485	-	395	Protein_1426	DUF5945 family protein	-
KCL43_RS07340 (KCL43_07340)	1552489..1552713	-	225	WP_165623642.1	DUF5965 family protein	-
KCL43_RS07345 (KCL43_07345)	1552767..1553853	-	1087	Protein_1428	toprim domain-containing protein	-
KCL43_RS07350 (KCL43_07350)	1553893..1554531	-	639	WP_165623643.1	peptidylprolyl isomerase	-
KCL43_RS07355 (KCL43_07355)	1554713..1556227	-	1515	WP_038674112.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1488176..1574755	86579

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (23-213)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 28763.80 Da
• Isoelectric Point: 6.7604

>T199640 WP_165623639.1 NZ_CP073275:c1551213-1550452 [Streptococcus equi subsp. zooepidemicus]
MRLEEFSKDDFDLALKRTIRSLTRGTTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLALQE
EYGKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTEIPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPSQARATPKEHHDGIVEYLVSNLRKLETDKLFDQIQIYQRDRTCVYDSGMDEGSAADVLQDCLFGKWSKVEEEML
KVGEEQLNELLKK

Nucleotide

• Length: 762 bp

>T199640 NZ_CP097427:c26696-26544 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18125.47 Da
• Isoelectric Point: 4.3858

>AT199640 WP_165623640.1 NZ_CP073275:c1551689-1551213 [Streptococcus equi subsp. zooepidemicus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLSDLINTKIYLVDTFDEVERYNGYLDGIERMLELAHHQVVA

Nucleotide

• Length: 477 bp

>AT199640 NZ_CP097427:26751-26808 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT