199634

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 407726..408416 Replicon plasmid unnamed1
Accession NZ_CP073263
Organism Duffyella gerundensis strain AR

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag J9874_RS19160 Protein ID WP_225701848.1
Coordinates 408036..408416 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag J9874_RS19155 Protein ID WP_187485379.1
Coordinates 407726..408055 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9874_RS19130 (J9874_03821) 403735..404274 - 540 WP_209502571.1 GNAT family N-acetyltransferase -
J9874_RS19135 (J9874_03822) 404483..404953 - 471 WP_225701847.1 DUF1203 domain-containing protein -
J9874_RS19140 (J9874_03823) 405244..406236 - 993 WP_067436333.1 zinc-dependent alcohol dehydrogenase family protein -
J9874_RS19145 (J9874_03824) 406375..407277 - 903 WP_209502577.1 LysR family transcriptional regulator -
J9874_RS19150 407587..407703 - 117 Protein_368 DNA polymerase III subunit theta -
J9874_RS19155 (J9874_03826) 407726..408055 - 330 WP_187485379.1 helix-turn-helix transcriptional regulator Antitoxin
J9874_RS19160 (J9874_03827) 408036..408416 - 381 WP_225701848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9874_RS19165 (J9874_03828) 408785..409618 - 834 WP_067436328.1 GIY-YIG nuclease family protein -
J9874_RS19170 (J9874_03829) 409862..410380 - 519 WP_209502589.1 GNAT family N-acetyltransferase -
J9874_RS19175 (J9874_03830) 410621..411238 - 618 WP_225701849.1 TetR/AcrR family transcriptional regulator -
J9874_RS19180 (J9874_03831) 411336..412514 + 1179 WP_225701850.1 4-hydroxybenzoate 3-monooxygenase -
J9874_RS19185 (J9874_03833) 412776..413381 - 606 WP_225701851.1 glutathione transferase GstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iutA / iucC 1..580636 580636


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14074.20 Da        Isoelectric Point: 9.4722

>T199634 WP_225701848.1 NZ_CP073263:c408416-408036 [Duffyella gerundensis]
MSLQGEKPLIWLGSSKKDLLSLPKEVQRFFGFALDFAQHGEKHDSAKVLKGFGDAGVLEVVEDDMGGTYRAVYTVKFDEA
VFVLHAFQKKSKQGIATPREDMEIIRNRLKVAAVVAQEIKNGKQNH

Download         Length: 381 bp

>T199634 NZ_CP097426:2605794-2605901 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11921.89 Da        Isoelectric Point: 9.7400

>AT199634 WP_187485379.1 NZ_CP073263:c408055-407726 [Duffyella gerundensis]
MENKIINGVTVEMSSGNIYADLNLKDAEKQKVKSGLAIEIIKNIRRLGLSQTAAGERMGISQAKVSNLLRGDFTNLSERK
LMECLNRLGCDIEIVIKPSASHTGHLKLA

Download         Length: 330 bp

>AT199634 NZ_CP097426:c2605747-2605681 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References