Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1800413..1801323 Replicon chromosome
Accession NZ_CP073262
Organism Duffyella gerundensis strain AR

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag J9874_RS08100 Protein ID WP_187485938.1
Coordinates 1800413..1800883 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag J9874_RS08105 Protein ID WP_209502121.1
Coordinates 1800880..1801323 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9874_RS08085 (J9874_01616) 1795990..1797480 - 1491 WP_225701693.1 PLP-dependent aminotransferase family protein -
J9874_RS08090 (J9874_01617) 1797589..1798875 + 1287 WP_225701694.1 4-aminobutyrate--2-oxoglutarate transaminase -
J9874_RS08095 (J9874_01618) 1798954..1800360 + 1407 WP_067430523.1 GABA permease -
J9874_RS08100 (J9874_01619) 1800413..1800883 - 471 WP_187485938.1 RES family NAD+ phosphorylase Toxin
J9874_RS08105 (J9874_01620) 1800880..1801323 - 444 WP_209502121.1 DUF2384 domain-containing protein Antitoxin
J9874_RS08110 (J9874_01622) 1801846..1803054 + 1209 WP_225701695.1 YcaO-like family protein -
J9874_RS08115 (J9874_01623) 1803060..1803890 + 831 WP_225701696.1 class I SAM-dependent methyltransferase -
J9874_RS08120 (J9874_01624) 1803924..1804721 - 798 WP_067430508.1 SIR2 family protein -
J9874_RS08125 (J9874_01625) 1804721..1805278 - 558 WP_067430506.1 non-canonical purine NTP pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-144)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17203.48 Da        Isoelectric Point: 5.1590

>T199631 WP_187485938.1 NZ_CP073262:c1800883-1800413 [Duffyella gerundensis]
VKLYRLTKTRYLSSAWSGYGAREGGGRWNNVGVSMVYASETASLTMLEILVHLQSAATLDAYTLLCVEVPDELIQWIDVT
QLPENWRAAEAPAALREIGDAWISSGESVALRIPSALSPVEHNFLLNPDHPAFTELVSRASHIPFMFDSRFGTAHS

Download         Length: 471 bp

>T199631 NZ_CP097426:2308614-2309936 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16627.05 Da        Isoelectric Point: 9.6528

>AT199631 WP_209502121.1 NZ_CP073262:c1801323-1800880 [Duffyella gerundensis]
MKQFTLPARHHSPERLWQVAGLNSADGVMLMGQIDRGLEGAVANRIISWALMTQADLRHVTGIPATTFNRGMKDRFTAEQ
SERLVRFIRVMDRAVELFEGDKHKAQQWLNEPARALDNKKPADLVSSETGAYEVLKLITRLEHGVYS

Download         Length: 444 bp

>AT199631 NZ_CP097426:2308348-2308614 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References