Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1435904..1436439 Replicon chromosome
Accession NZ_CP073262
Organism Duffyella gerundensis strain AR

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J9874_RS06380 Protein ID WP_225701593.1
Coordinates 1435904..1436191 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J9874_RS06385 Protein ID WP_225701594.1
Coordinates 1436197..1436439 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9874_RS06360 (J9874_01271) 1431460..1432539 + 1080 WP_187486089.1 two-component system sensor histidine kinase PmrB -
J9874_RS06365 (J9874_01273) 1432842..1433249 + 408 WP_225701590.1 S24 family peptidase -
J9874_RS06370 (J9874_01274) 1433467..1434141 + 675 WP_225701591.1 hypothetical protein -
J9874_RS06375 (J9874_01275) 1434616..1435875 + 1260 WP_225701592.1 translesion error-prone DNA polymerase V subunit UmuC -
J9874_RS06380 (J9874_01276) 1435904..1436191 - 288 WP_225701593.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9874_RS06385 (J9874_01277) 1436197..1436439 - 243 WP_225701594.1 antitoxin Antitoxin
J9874_RS06390 (J9874_01278) 1437114..1437907 + 794 Protein_1228 trehalose-phosphatase -
J9874_RS06395 (J9874_01279) 1437904..1439340 + 1437 WP_209501910.1 alpha,alpha-trehalose-phosphate synthase -
J9874_RS06400 (J9874_01280) 1440406..1440762 + 357 WP_209502222.1 flagellar transcriptional regulator FlhD -
J9874_RS06405 (J9874_01281) 1440759..1441337 + 579 WP_209501912.1 flagellar transcriptional regulator FlhC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10959.93 Da        Isoelectric Point: 10.4613

>T199630 WP_225701593.1 NZ_CP073262:c1436191-1435904 [Duffyella gerundensis]
MGYTIKIREEALKEWNGLDSIIREQFKKKLKKPLENPHIPAARLSGMPDCYKINLRASGFRLVYQVMDDVLIVAVVAVGK
RERSQAYKLASERLR

Download         Length: 288 bp

>T199630 NZ_CP097426:2254315-2254602 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8842.27 Da        Isoelectric Point: 4.3297

>AT199630 WP_225701594.1 NZ_CP073262:c1436439-1436197 [Duffyella gerundensis]
MANLILSDTSASVSELKKKPMATVEAGAGMPVTILNRNQPVFYCVPAHLYEKMLEIIDDQELATLVKARENQPLLDLDLD

Download         Length: 243 bp

>AT199630 NZ_CP097426:2254076-2254315 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References