Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1725718..1726319 Replicon chromosome
Accession NZ_CP073248
Organism Proteus mirabilis strain N292

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag KCV17_RS08185 Protein ID WP_049220154.1
Coordinates 1725936..1726319 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag KCV17_RS08180 Protein ID WP_004246496.1
Coordinates 1725718..1725939 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCV17_RS08155 1721502..1721960 + 459 WP_004246490.1 dUTP diphosphatase -
KCV17_RS08160 1722080..1722685 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
KCV17_RS08165 1723005..1723649 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
KCV17_RS08170 1723731..1724447 - 717 WP_004249760.1 ribonuclease PH -
KCV17_RS08175 1724574..1725437 + 864 WP_004249947.1 YicC/YloC family endoribonuclease -
KCV17_RS08180 1725718..1725939 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KCV17_RS08185 1725936..1726319 + 384 WP_049220154.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KCV17_RS08190 1726727..1727041 + 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
KCV17_RS08195 1727054..1728292 + 1239 WP_004246499.1 HipA domain-containing protein -
KCV17_RS08200 1728649..1729548 - 900 WP_017628715.1 N-acetylmuramic acid 6-phosphate etherase -
KCV17_RS08205 1729657..1730394 + 738 WP_004249950.1 tetratricopeptide repeat protein -
KCV17_RS08210 1730490..1730948 - 459 WP_004249766.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14452.48 Da        Isoelectric Point: 7.4666

>T199626 WP_049220154.1 NZ_CP073248:1725936-1726319 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIHDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T199626 NZ_CP097426:1750535-1750786 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT199626 WP_004246496.1 NZ_CP073248:1725718-1725939 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT199626 NZ_CP097426:1750783-1751037 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References