Detailed information of TA system TA199623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2969540..2971111
• Replicon: chromosome
• Accession: NZ_CP073247
• Organism: Proteus mirabilis strain S62-3-2-2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KCV16_RS13730
• Protein ID: WP_104731898.1
• Coordinates: 2969798..2971111 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: KCV16_RS13725
• Protein ID: WP_004249771.1
• Coordinates: 2969540..2969797 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCV16_RS13690	2965210..2965557	+	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-
KCV16_RS13695	2965551..2966388	+	838	Protein_2653	sulfonamide-resistant dihydropteroate synthase Sul1	-
KCV16_RS13700	2966516..2967016	+	501	WP_000376623.1	GNAT family N-acetyltransferase	-
KCV16_RS13705	2967337..2967405	+	69	Protein_2655	EAL domain-containing protein	-
KCV16_RS13710	2967523..2968287	+	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
KCV16_RS13715	2968427..2968492	-	66	Protein_2657	EAL domain-containing protein	-
KCV16_RS13720	2968635..2969264	+	630	WP_001145449.1	hypothetical protein	-
KCV16_RS13725	2969540..2969797	+	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
KCV16_RS13730	2969798..2971111	+	1314	WP_104731898.1	type II toxin-antitoxin system HipA family toxin	Toxin
KCV16_RS13735	2971513..2971977	+	465	WP_004246516.1	DUF1097 domain-containing protein	-
KCV16_RS13740	2972162..2973091	+	930	WP_004246518.1	metallophosphoesterase	-
KCV16_RS13745	2973123..2975084	+	1962	WP_172764490.1	insecticidal delta-endotoxin Cry8Ea1 family protein	-
KCV16_RS13750	2975138..2975941	-	804	WP_004249775.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49697.85 Da
• Isoelectric Point: 6.6588

>T199623 WP_104731898.1 NZ_CP073247:2969798-2971111 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDVKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T199623 NZ_CP097426:712823-713119 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT199623 WP_004249771.1 NZ_CP073247:2969540-2969797 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT199623 NZ_CP097426:713121-713516 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: B4F0T9