Detailed information of TA system TA199622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2853684..2854285
• Replicon: chromosome
• Accession: NZ_CP073247
• Organism: Proteus mirabilis strain S62-3-2-2

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: KCV16_RS13130
• Protein ID: WP_049196622.1
• Coordinates: 2853902..2854285 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: KCV16_RS13125
• Protein ID: WP_004246496.1
• Coordinates: 2853684..2853905 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCV16_RS13100	2849469..2849927	+	459	WP_004246490.1	dUTP diphosphatase	-
KCV16_RS13105	2850047..2850652	+	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
KCV16_RS13110	2850971..2851615	-	645	WP_060557242.1	orotate phosphoribosyltransferase	-
KCV16_RS13115	2851697..2852413	-	717	WP_004249760.1	ribonuclease PH	-
KCV16_RS13120	2852540..2853403	+	864	WP_060557243.1	YicC/YloC family endoribonuclease	-
KCV16_RS13125	2853684..2853905	+	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KCV16_RS13130	2853902..2854285	+	384	WP_049196622.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KCV16_RS13135	2854446..2855345	-	900	WP_063108742.1	N-acetylmuramic acid 6-phosphate etherase	-
KCV16_RS13140	2855454..2856191	+	738	WP_004249950.1	tetratricopeptide repeat protein	-
KCV16_RS13145	2856287..2856745	-	459	WP_150452832.1	GNAT family N-acetyltransferase	-
KCV16_RS13150	2856874..2858361	+	1488	WP_150452831.1	PLP-dependent aminotransferase family protein	-
KCV16_RS13155	2858417..2858986	-	570	WP_004249768.1	rRNA adenine N-6-methyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14529.57 Da
• Isoelectric Point: 7.4005

>T199622 WP_049196622.1 NZ_CP073247:2853902-2854285 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T199622 NZ_CP097426:648250-648564 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT199622 WP_004246496.1 NZ_CP073247:2853684-2853905 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT199622 NZ_CP097426:648561-648977 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9