Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3388091..3388702 Replicon chromosome
Accession NZ_CP073246
Organism Proteus mirabilis strain N639-2X

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KCV15_RS15560 Protein ID WP_237075908.1
Coordinates 3388349..3388702 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag KCV15_RS15555 Protein ID WP_004249771.1
Coordinates 3388091..3388348 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCV15_RS15540 3384765..3385652 + 888 WP_249121595.1 sce7726 family protein -
KCV15_RS15545 3385659..3386591 + 933 WP_196547349.1 sce7725 family protein -
KCV15_RS15550 3386594..3387622 + 1029 WP_196547350.1 RES family NAD+ phosphorylase -
KCV15_RS15555 3388091..3388348 + 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
KCV15_RS15560 3388349..3388702 + 354 WP_237075908.1 HipA N-terminal domain-containing protein Toxin
KCV15_RS15565 3389041..3389505 + 465 WP_012368636.1 DUF1097 domain-containing protein -
KCV15_RS15570 3389690..3390619 + 930 WP_004246518.1 metallophosphoesterase -
KCV15_RS15575 3390651..3392612 + 1962 WP_211849690.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
KCV15_RS15580 3392666..3393469 - 804 WP_060554978.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13114.70 Da        Isoelectric Point: 4.5238

>T199620 WP_237075908.1 NZ_CP073246:3388349-3388702 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIE

Download         Length: 354 bp

>T199620 NZ_CP097426:183506-183613 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT199620 WP_004249771.1 NZ_CP073246:3388091-3388348 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT199620 NZ_CP097426:c183458-183392 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References