Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1843723..1845470 Replicon chromosome
Accession NZ_CP073244
Organism Proteus terrae subsp. cibarius strain M878-2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KCV11_RS08280 Protein ID WP_098941872.1
Coordinates 1844097..1845470 (-) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KCV11_RS08275 Protein ID WP_098941871.1
Coordinates 1843723..1844100 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCV11_RS08250 1839623..1841356 + 1734 WP_075673441.1 hydrogenase large subunit -
KCV11_RS08255 1841368..1841922 + 555 WP_075673442.1 hydrogenase 4 subunit H -
KCV11_RS08260 1841919..1842701 + 783 WP_072069032.1 NADH-quinone oxidoreductase subunit B family protein -
KCV11_RS08265 1842694..1843104 + 411 WP_088494545.1 formate hydrogenlyase maturation HycH family protein -
KCV11_RS08270 1843101..1843601 + 501 WP_098941870.1 hydrogenase maturation peptidase HycI -
KCV11_RS08275 1843723..1844100 - 378 WP_098941871.1 helix-turn-helix transcriptional regulator Antitoxin
KCV11_RS08280 1844097..1845470 - 1374 WP_098941872.1 HipA domain-containing protein Toxin
KCV11_RS08285 1845853..1846842 + 990 WP_098941873.1 glycosyltransferase -
KCV11_RS08290 1847256..1848839 + 1584 WP_098941874.1 ABC transporter substrate-binding protein -
KCV11_RS08295 1848824..1849807 + 984 WP_098941875.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52589.44 Da        Isoelectric Point: 4.6415

>T199613 WP_098941872.1 NZ_CP073244:c1845470-1844097 [Proteus terrae subsp. cibarius]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

>T199613 NZ_CP097423:2368550-2368652 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14108.43 Da        Isoelectric Point: 10.5220

>AT199613 WP_098941871.1 NZ_CP073244:c1844100-1843723 [Proteus terrae subsp. cibarius]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Download         Length: 378 bp

>AT199613 NZ_CP097423:c2368658-2368514 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References