Detailed information of TA system TA199610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1248975..1250546
• Replicon: chromosome
• Accession: NZ_CP073244
• Organism: Proteus terrae subsp. cibarius strain M878-2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KCV11_RS05705
• Protein ID: WP_098941509.1
• Coordinates: 1249233..1250546 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KCV11_RS05700
• Protein ID: WP_072070485.1
• Coordinates: 1248975..1249232 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCV11_RS05675	1244944..1245087	+	144	WP_004246509.1	50S ribosomal protein L34	-
KCV11_RS05680	1245105..1245464	+	360	WP_071788569.1	ribonuclease P protein component	-
KCV11_RS05685	1245428..1245688	+	261	WP_072064717.1	membrane protein insertion efficiency factor YidD	-
KCV11_RS05690	1245691..1247331	+	1641	WP_098941508.1	membrane protein insertase YidC	-
KCV11_RS05695	1247462..1248826	+	1365	WP_023583363.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
KCV11_RS05700	1248975..1249232	+	258	WP_072070485.1	helix-turn-helix domain-containing protein	Antitoxin
KCV11_RS05705	1249233..1250546	+	1314	WP_098941509.1	type II toxin-antitoxin system HipA family toxin	Toxin
KCV11_RS05710	1251555..1252016	+	462	WP_098941511.1	DUF1097 domain-containing protein	-
KCV11_RS05715	1252117..1252896	-	780	WP_098941512.1	ABC transporter ATP-binding protein	-
KCV11_RS05720	1252977..1255058	-	2082	WP_198801053.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49636.50 Da
• Isoelectric Point: 5.8274

>T199610 WP_098941509.1 NZ_CP073244:1249233-1250546 [Proteus terrae subsp. cibarius]
MASLDVYMNEYYVGIFTKKSSGAHSFQYAEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNPEIRNRIVSRYN
ANSNQPFDLLTAVGADTVGALRLLPSSSTPANIKKIEYNKLDNAELEKILLGYQSNTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCFIVKTENIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMNYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLQASRGKKYAIEQIFPRHFYQTAEAASFDPSLMTDILRYFYKEM
DDAIKRVKQQLPDDFPSEISSKILNGMKTRSARLANI

Nucleotide

• Length: 1314 bp

>T199610 NZ_CP097423:786646-786993 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9848.40 Da
• Isoelectric Point: 10.0139

>AT199610 WP_072070485.1 NZ_CP073244:1248975-1249232 [Proteus terrae subsp. cibarius]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT199610 NZ_CP097423:786993-787292 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA