Detailed information of TA system TA199608

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2057565..2058218
• Replicon: chromosome
• Accession: NZ_CP073243
• Organism: Acinetobacter seifertii strain S63-3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KCV10_RS09610
• Protein ID: WP_151760873.1
• Coordinates: 2057829..2058218 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N8SCE2
• Locus tag: KCV10_RS09605
• Protein ID: WP_002049719.1
• Coordinates: 2057565..2057822 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCV10_RS09585	2053079..2054086	+	1008	WP_004705386.1	DNA-directed RNA polymerase subunit alpha	-
KCV10_RS09590	2054105..2054482	+	378	WP_002049717.1	50S ribosomal protein L17	-
KCV10_RS09595	2054664..2056154	+	1491	WP_212510856.1	NAD(P)/FAD-dependent oxidoreductase	-
KCV10_RS09600	2056203..2057375	-	1173	WP_151760872.1	acyl-CoA dehydrogenase family protein	-
KCV10_RS09605	2057565..2057822	+	258	WP_002049719.1	succinate dehydrogenase assembly factor 2	Antitoxin
KCV10_RS09610	2057829..2058218	+	390	WP_151760873.1	hypothetical protein	Toxin
KCV10_RS09615	2058987..2060072	+	1086	WP_019457778.1	hypothetical protein	-
KCV10_RS09620	2060157..2060723	+	567	WP_151760874.1	rhombosortase	-
KCV10_RS09625	2060911..2063106	+	2196	WP_019457776.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15522.56 Da
• Isoelectric Point: 10.1482

>T199608 WP_151760873.1 NZ_CP073243:2057829-2058218 [Acinetobacter seifertii]
MINQLNFKLKYSRFAIVFQFFIGLSLAVLFYQLLPILWWLITVSLLFISFVLFLKRSQVAQIAYLDQKLWSLSFHSEQTI
SRVEILKIIDYQIFIVVYFKGDKTLTSVIWFDQMSLSQWKQLKTLEKFY

Nucleotide

• Length: 390 bp

>T199608 NZ_CP097423:c358518-358135 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10278.71 Da
• Isoelectric Point: 4.7620

>AT199608 WP_002049719.1 NZ_CP073243:2057565-2057822 [Acinetobacter seifertii]
MSEEMTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT199608 NZ_CP097423:c358760-358518 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A0Q1QI86